斯普利特麻一辛结构式
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常用名 | 斯普利特麻一辛 | 英文名 | Splitomicin |
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| CAS号 | 5690-03-9 | 分子量 | 198.217 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 383.6±17.0 °C at 760 mmHg | |
| 分子式 | C13H10O2 | 熔点 | 73-74.5℃ | |
| MSDS | 中文版 美版 | 闪点 | 161.2±18.4 °C |
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SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis.
Eur. Heart J. 31 , 2301-9, (2010) Endothelial activation, macrophage infiltration, and foam cell formation are pivotal steps in atherogenesis. Our aim in this study was to analyse the role of SIRT1, a class III deacetylase with important metabolic functions, in plaque macrophages and atheroge... |
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Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.
PLoS ONE 4(6) , e6093, (2009) The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus eradication. Activation of HIV-1 gene expression in these ... |
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Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells.
Cardiovasc. Res. 89 , 464-72, (2011) The mammalian silent information regulator-two 1 (Sirt1) blunts the noxious effects of cardiovascular risk factors such as type 2 diabetes mellitus and obesity. Nevertheless, the role of Sirt1 in regulating the expression of tissue factor (TF), the key trigge... |
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SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice.
Aging (Albany. NY.) 2 , 353-60, (2010) Excessive production of reactive oxygen species (ROS) contributes to progression of atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory activation. The class III histone deacetylase SIRT1 has been implicated in extension of l... |
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The Sir2 family of protein deacetylases.
Annu. Rev. Biochem. 73 , 417-35, (2004) The yeast SIR protein complex has been implicated in transcription silencing and suppression of recombination. The Sir complex represses transcription at telomeres, mating-type loci, and ribosomal DNA. Unlike SIR3 and SIR4, the SIR2 gene is highly conserved i... |
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Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis.
J. Biol. Chem. 286 , 4264-70, (2011) In unstressed cells, the p53 tumor suppressor is highly unstable. DNA damage and other forms of cellular stress rapidly stabilize and activate p53. This process is regulated by a complex array of post-translational modifications that are dynamically deposited... |
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Splitomicin suppresses human platelet aggregation via inhibition of cyclic AMP phosphodiesterase and intracellular Ca++ release.
Thromb. Res. 124(2) , 199-207, (2009) Splitomicin is derived from beta-naphthol and is an inhibitor of Silent Information Regulator 2 (SIR2). Its naphthoic moiety might be responsible for its inhibitory effects on platelets. The major goal of our study was to examine possible mechanisms of action... |
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Recombinant lactobacillus expressing G protein of spring viremia of carp virus (SVCV) combined with ORF81 protein of koi herpesvirus (KHV): A promising way to induce protective immunity against SVCV and KHV infection in cyprinid fish via oral vaccination.
Blood 125(4) , 710-9, (2015) Spring viremia of carp virus (SVCV) and koi herpesvirus (KHV) are highly contagious and pathogenic to cyprinid fish, causing enormous economic losses in aquaculture. Although DNA vaccines reported in recent years could induce protective immune responses in ca... |