N-叔丁基-α-苯基硝酮

Anticancer Res. 31(2) , 487-94, (2011)

It has been reported that human prostate-derived PC-3 cells that are CD44- and CD 41 (a2 B1)-positive are enriched in cancer stem cells. This study compared the effect of PC-3 cell proliferation under normoxia or hypoxia on the initial and subsequent expressi...

J. Interferon Cytokine Res. 35(3) , 143-56, (2015)

Hydroxychloroquine (HCQ) is an antimalarial drug also used in treating autoimmune diseases. Its antiviral activity was demonstrated in restricting HIV infection in vitro; however, the clinical implications remain controversial. Infection with dengue virus (DE...

PLoS ONE 10 , e0136450, (2015)

Quinoxaline 1,4-di-N-oxides (QdNOs) are widely known as potent antibacterial agents, but their antibacterial mechanisms are incompletely understood. In this study, the transcriptomic and proteomic profiles of Escherichia coli exposed to QdNOs were integrative...

J. Pharmacol. Exp. Ther. 351(3) , 568-75, (2014)

Peripheral postischemic dysesthesia was examined behaviorally in mice and we investigated the underlying molecular mechanism with a focus on oxidative stress. Hind-paw ischemia was induced by tight compression of the ankle with a rubber band, and reperfusion ...

Toxicol. Appl. Pharmacol. 273(3) , 508-15, (2013)

Oxidative stress and reactive oxygen species (ROS) have been implicated in the teratogenicity of methanol (MeOH) in rodents, both in vivo and in embryo culture. We explored the ROS hypothesis further in vivo in pregnant C57BL/6J mice. Following maternal treat...

Anticancer Agents Med. Chem. 11(4) , 373-9, (2011)

The nitrone compound PBN, α-phenyl-tert-butylnitrone, and closely related nitrones have anti-cancer activity in several experimental cancer models. The three experimental models most extensively studied include A) the rat choline deficiency liver cancer model...

J. Neurochem. 124(4) , 523-35, (2013)

Oxidative stress after stroke is associated with the inflammatory system activation in the brain. The complement cascade, especially the degradation products of complement component 3, is a key inflammatory mediator of cerebral ischemia. We have shown that pr...

Brain Res. 1412 , 28-36, (2011)

Haloperidol (HP) is a widely prescribed antipsychotic drug used for the treatment of mental disorders. However, while providing therapeutic benefits, this drug also causes serious extrapyramidal side effects, such as tardive dyskinesia (TD). Upon chronic admi...

J. Neurochem. 117(3) , 437-48, (2011)

Brain edema and associated increased intracranial pressure are major consequences of traumatic brain injury (TBI). An important early component of the edema associated with TBI is astrocyte swelling (cytotoxic edema). Mechanisms for such swelling, however, ar...

J. Phys. Chem. A 114(21) , 6217-25, (2010)

We present electron spin resonance (ESR) experiments that describe the interaction of beta-cyclodextrin (beta-CD) with spin adducts of three spin traps: 5,5-dimethyl-1-pyrroline N-oxide (DMPO), N-tert-butyl-alpha-phenylnitrone (PBN), and 2-methyl-2-nitrosopro...