甘氨酸酐
甘氨酸酐结构式
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常用名 | 甘氨酸酐 | 英文名 | Glycine Anhydride |
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| CAS号 | 106-57-0 | 分子量 | 114.103 | |
| 密度 | 1.2±0.1g/cm3 | 沸点 | 573.7±43.0°C at 760 mmHg | |
| 分子式 | C4H6N2O2 | 熔点 | 300°C | |
| MSDS | 中文版 美版 | 闪点 | 301.9±28.3°C |
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Design and synthesis of novel soluble 2,5-diketopiperazine derivatives as potential anticancer agents.
Eur. J. Med. Chem. 83 , 236-44, (2014) Non-protected 2,5-diketopiperazine derivatives have poor solubility thus with negative impact on their bioavailability. In the present study, twenty-one novel soluble mono-protected, and three non-protected 2,5-diketopiperazine derivatives were designed and s... |
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Rational design and combinatorial evaluation of enzyme inhibitor scaffolds: identification of novel inhibitors of matrix metalloproteinases.
J. Med. Chem. 41(13) , 2194-200, (1998) The discovery of a novel series of heterocyclic matrix metalloproteinase (MMPs) inhibitors is described. Published crystal structures of peptidyl hydroxamates bound to MMPs were the basis for the rational design of diketopiperazine (DKP) inhibitors. Combinato... |
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Diagnostic NH and OH vibrations for oxazolone and diketopiperazine structures: b2 from protonated triglycine.
J. Am. Soc. Mass Spectrom. 22 , 1197-1203, (2011) We present infrared multiple photon dissociation (IRMPD) spectra in the hydrogen stretching region of the simplest b fragment, b(2) from protonated triglycine, contrasted to that of protonated cyclo(Gly-Gly). Both spectra confirm the presence of intense, diag... |
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Determination of the decomposition products of Usal in model systems and determination of dioxopiperazine in soft drinks by HPLC.
Nahrung 29(4) , 381-9, (1985) A HPLC method for the determination of Usal (Aspartame hydrochloride, L-aspartyl-L-phenylalanine methyl ester hydrochloride) and its decomposition products was elaborated. Aspartic acid, phenylalanine, phenylalanine methyl ester, aspartyl-phenylalanine, pheny... |
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Acid catalysis in the formation of dioxopiperazines from peptides containing tetrahydroisoquinoline-3-carboxylic acid at position 2.
Int. J. Pept. Protein Res. 45(6) , 567-73, (1995) The kinetics of the spontaneous formation of 2,5-dioxopiperazines from peptides containing the Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) residue in the 2-position of the sequence has been studied in DMSO and water solution. The reaction is first ... |
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A sensitive high performance liquid chromatographic assay of a new metabolite of ampicillin in man.
J. Pharm. Pharmacol. 38(3) , 225-6, (1986) A sensitive, high-performance liquid chromatographic method has been developed for the determination of piperazine-2,5-dione, a new metabolite of ampicillin, in human urine. Piperazine-2,5-dione was separated from human urine on a C18-column using phosphate b... |
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Role of endogenous cyclo(His-Pro) in cold-induced hypothermia in the desert rat (Mastomys natalensis).
Peptides 15(8) , 1471-4, (1994) Central administration of exogenous cyclo(His-Pro) (CHP) is known to produce hypothermia in rodents. In the present study, we examined the role of endogenous CHP in cold-induced hypothermia in the desert rat, Mastomys natalensis. The results of these studies ... |
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Synchrotron vacuum ultraviolet (VUV) photo-induced fragmentation of cyclic dipeptides radical cations.
Amino Acids 43(1) , 279-87, (2012) Cyclic dipeptides, due to their chemical properties and various bioactivities, are very attractive for medicinal chemistry. Fragmentations of three simple cyclic dipeptides including cyclo(Gly-Gly), cyclo(Ala-Ala) and cyclo(Gly-Val) in the gas-phase are deter... |