4-硝基苯基-α-D-吡喃甘露糖苷
4-硝基苯基-α-D-吡喃甘露糖苷结构式
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常用名 | 4-硝基苯基-α-D-吡喃甘露糖苷 | 英文名 | 4-Nitrophenyl α-D-mannopyranoside |
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| CAS号 | 10357-27-4 | 分子量 | 301.249 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 582.2±50.0 °C at 760 mmHg | |
| 分子式 | C12H15NO8 | 熔点 | 179-181ºC | |
| MSDS | 美版 | 闪点 | 305.9±30.1 °C |
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Synthesis of glycopeptide dendrimers, dimerization and affinity for Concanavalin A.
Bioorg. Med. Chem. 19 , 2879-87, (2011) We described herein the synthesis of second generation glycopeptide dendrimers G2a-g presenting variable amino acids placed internally into the multivalent scaffold. The effect of such structural modulation on recognition processes by Concanavalin A (Con A), ... |
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ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug.
Haematologica 94 , 1528-36, (2009) Inhibition of BCR-ABL tyrosine kinase activity has evolved as a mainstay of therapy for patients with chronic myeloid leukemia. However, a fraction of leukemic cells persists under targeted therapy and can lead to disease progression on cessation of treatment... |
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Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont.
Nat. Chem. Biol. 6 , 125-32, (2010) Colonic bacteria, exemplified by Bacteroides thetaiotaomicron, play a key role in maintaining human health by harnessing large families of glycoside hydrolases (GHs) to exploit dietary polysaccharides and host glycans as nutrients. Such GH family expansion is... |
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Frontal affinity chromatography of ovalbumin glycoasparagines on a concanavalin A-sepharose column. A quantitative study of the binding specificity of the lectin.
J. Biol. Chem. 260(11) , 6882-7, (1985) The interactions of Sepharose 4B-immobilized concanavalin A (ConA) with 10 glycoasparagines derived from ovalbumin were investigated quantitatively by frontal affinity chromatography. In this method, a carbohydrate solution is applied continuously to a ConA-S... |
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Characterization of a specific alpha-mannosidase involved in oligosaccharide processing in Saccharomyces cerevisiae.
J. Biol. Chem. 260(4) , 2253-7, (1985) Fractionation of a crude extract from Saccharomyces cerevisiae X-2180 on Sepharose 6B in the presence of 0.5% Triton X-100 resolves two enzyme fractions containing alpha-mannosidase activity. Fraction I which is excluded from the gel contains alpha-mannosidas... |
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[Inhibition of peritoneal bacterial adhesion using oligosaccharides. An experimental model of peritonitis in rats].
Chirurgie 124(2) , 159-64, (1999) Peritoneal colonization is a crucial event in the pathogenesis of peritonitis and its local complications. Adherence to the serosal mesothelium is mediated in a number of microorganisms derived from the digestive tract (especially E. coli) by type-1 fimbriae ... |
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Structure-based drug design and optimization of mannoside bacterial FimH antagonists.
J. Med. Chem. 53 , 4779-92, (2010) FimH-mediated cellular adhesion to mannosylated proteins is critical in the ability of uropathogenic E. coli (UPEC) to colonize and invade the bladder epithelium during urinary tract infection. We describe the discovery and optimization of potent small-molecu... |
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Human lysosomal and jack bean alpha-mannosidases are retaining glycosidases.
Biochem. Biophys. Res. Commun. 238(3) , 896-8, (1997) The stereochemical course of the hydrolyses catalysed by two alpha-mannosidases has been determined directly by 1H NMR. Synthetic substrates were incubated with the enzymes and the anomeric configuration of the initially formed product was ascertained in each... |
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The crystal structure of the complexes of concanavalin A with 4'-nitrophenyl-alpha-D-mannopyranoside and 4'-nitrophenyl-alpha-D-glucopyranoside.
J. Struct. Biol. 116(3) , 345-55, (1996) Concanavalin A (Con A) is the best-known plant lectin and has important in vitro biological activities arising from its specific saccharide-binding ability. Its exact biological role still remains unknown. The complexes of Con A with 4'-nitrophenyl-alpha-D-ma... |
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Serum beta-(1----4)-galactosyltransferase activity with synthetic low molecular weight acceptor in human ovarian cancer.
Eur. J. Cancer Clin. Oncol. 23(7) , 901-6, (1987) A modified procedure was developed for the determination of UDP-galactose: 2-acetamido-2-deoxy-glucopyranoside beta-(1----4)-galactosyltransferase (GT) in human serum which employed the synthetic substrates p-nitrophenyl 6-0-(2-acetamido-2-deoxy-beta-D-glucop... |