胰高血糖素样肽1(7-36)酰胺(人,大鼠)结构式
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常用名 | 胰高血糖素样肽1(7-36)酰胺(人,大鼠) | 英文名 | GLP-1 (7-36) amide (human, bovine, guinea pig, mouse, rat) trifluoroacetate salt |
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| CAS号 | 107444-51-9 | 分子量 | 3297.630 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C149H226N40O45 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39).
Metab. Clin. Exp. 53(2) , 252-9, (2004) The incretin hormone glucagon-like peptide-1(7-36)amide (GLP-1) has been deemed of considerable importance in the regulation of blood glucose. Its effects, mediated through the regulation of insulin, glucagon, and somatostatin, are glucose-dependent and contr... |
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Coexpression of glucagon-like peptide-1 (GLP-1) receptor, vasopressin, and oxytocin mRNAs in neurons of the rat hypothalamic supraoptic and paraventricular nuclei: effect of GLP-1(7-36)amide on vasopressin and oxytocin release.
J. Neurochem. 72(1) , 10-6, (1999) This study was designed to gain better insight into the relationship between glucagon-like peptide-1 (GLP-1) (7-36) amide and vasopressin (AVP) and oxytocin (OX). In situ hybridization histochemistry revealed colocalization of the mRNAs for GLP-1 receptor, AV... |
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Elevated post-prandial gastric inhibitory polypeptide concentrations in hypertriglyceridaemic subjects.
Clin. Sci. 93(4) , 343-7, (1997) 1. We investigated whether abnormalities of gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (7-36 amide) (GLP-1) contribute to the hypertriglyceridaemia and hyperinsulinaemia in hypertriglyceridaemic subjects. Serum triglycerides and plasma g... |
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Simultaneous determination of incretin hormones and their truncated forms from human plasma by immunoprecipitation and liquid chromatography-mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 803(1) , 91-9, (2004) The incretins, glucose-dependent insulinotropic peptide (GIP(1-42)) and glucagon-like peptide 1 (GLP-1(7-36)), are involved in regulation of gastric emptying, glucose homeostasis, body fat regulation and the glucose-induced insulin secretion from the endocrin... |
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Intracerebroventricular glucagon-like peptide-1 (7-36) amide inhibits sham feeding in rats without eliciting satiety.
Physiol. Behav. 64(3) , 367-72, (1998) Glucagonlike peptide-1 (7-36) amide (GLP-1) and its receptors are present in several brain regions and may play a role in the physiological control of feeding. To investigate the effect of GLP-1 on eating in the absence of postingestive food stimuli, rats wer... |
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Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats.
Pharmacology 74(3) , 119-26, (2005) We investigated the vascular effects of glucagon-like peptide-1 (GLP-1) and Exendin-4 in type 2 diabetic rat aortae. Studies were performed in a normal control group (NC) (0.2 ml i.p. saline, n = 10), streptozotocin (STZ)/nicotinamide diabetic control group (... |
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Effects of various N-terminal fragments of glucagon-like peptide-1(7-36) on food intake in the neonatal chick.
Brain Res. 807(1-2) , 214-7, (1998) Recently, the suppressive effect on food intake by the central administration of glucagon-like peptide-1 (GLP-1) has been confirmed in both rats and chicks. The importance of the N-terminal amino acid, histidine, for the bioactivity of GLP-1(7-36) in the cent... |
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The entero-insular axis in type 2 diabetes--incretins as therapeutic agents.
Exp. Clin. Endocrinol. Diabetes 109 Suppl 2 , S288-303, (2001) The search for intestinal factors regulating the endocrine secretion of the pancreas started soon after the discovery of secretin, i.e. nearly 100 years ago. Insulinotropic factors of the gut released by nutrients and stimulating insulin secretion in physiolo... |
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Changes in the concentrations of glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide during the lactation cycle in goats.
J. Dairy Res. 65(3) , 433-41, (1998) Plasma concentrations of glucagon-like peptide-1(7-36)amide (GLP) and gastric inhibitory polypeptide (GIP) were determined at fortnightly intervals for over a year throughout the pregnancy-lactation cycle of goats. Both GIP and GLP concentrations were elevate... |
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Evaluation of glycated glucagon-like peptide-1(7-36)amide in intestinal tissue of normal and diabetic animal models.
Biochim. Biophys. Acta 1569(1-3) , 75-80, (2002) Glucagon-like peptide-1(7-36)amide (tGLP-1) is an important insulin-releasing hormone of the enteroinsular axis which is secreted by endocrine L-cells of the small intestine following nutrient ingestion. The present study has evaluated tGLP-1 in the intestine... |