青蟹肌醇
青蟹肌醇结构式
|
常用名 | 青蟹肌醇 | 英文名 | scyllo-Inositol |
|---|---|---|---|---|
| CAS号 | 488-59-5 | 分子量 | 180.156 | |
| 密度 | 2.0±0.1 g/cm3 | 沸点 | 291.3±40.0 °C at 760 mmHg | |
| 分子式 | C6H12O6 | 熔点 | 350ºC | |
| MSDS | 中文版 美版 | 闪点 | 143.4±21.9 °C |
|
Verifying the botanical authenticity of commercial tannins through sugars and simple phenols profiles.
Food Chem. 206 , 274-83, (2016) Commercial tannins from several botanical sources and with different chemical and technological characteristics are used in the food and winemaking industries. Different ways to check their botanical authenticity have been studied in the last few years, throu... |
|
|
High cerebral scyllo-inositol: a new marker of brain metabolism disturbances induced by chronic alcoholism.
MAGMA 17(1) , 47-61, (2004) Cerebral metabolic changes that concur to motor and/or cognitive disorders in actively drinking alcoholics are not well established. We tested the hypothesis that chronic alcoholics exhibit profound alterations in the cerebral metabolism of scyllo-inositol. B... |
|
|
β-Amyloid peptides and amyloid plaques in Alzheimer's disease.
Neurotherapeutics 12(1) , 3-11, (2015) Many lines of evidence support that β-amyloid (Aβ) peptides play an important role in Alzheimer's disease (AD), the most common cause of dementia. But despite much effort the molecular mechanisms of how Aβ contributes to AD remain unclear. While Aβ is generat... |
|
|
Prediction of variability in CYP3A4 induction using a combined 1H NMR metabonomics and targeted UPLC-MS approach.
J. Proteome Res. 10(6) , 2807-16, (2011) The activity of Cytochrome P450 3A4 (CYP3A4) enzyme is associated with many adverse or poor therapeutic responses to drugs. We used (1)H NMR-based metabonomics to identify a metabolic signature associated with variation in induced CYP3A4 activity. A total of ... |
|
|
Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation.
Bioorg. Med. Chem. 16 , 7177-84, (2008) scyllo-Inositol has shown promise as a potential therapeutic for Alzheimer's disease, by directly interacting with the amyloid beta (Abeta) peptide to inhibit Abeta42 fiber formation. To explore the molecular details of the inositol-Abeta42 interaction, a ser... |
|
|
Polyphosphate kinases modulate Campylobacter jejuni outer membrane constituents and alter its capacity to invade and survive in intestinal epithelial cells in vitro.
Emerg Microbes Infect 4 , e77, (2015) Campylobacter jejuni is the most prevalent cause of bacterial gastroenteritis worldwide. Polyphosphate kinases 1 and 2 (PPK1 and PPK2) regulate several cellular processes, including the biosynthesis of the bacterial cell wall. Despite their importance, whethe... |
|
|
Amyloid-β fibrillogenesis: Structural insight and therapeutic intervention
Exp. Neurol. 223(2) , 311-21, (2010) Structural insight into the conformational changes associated with aggregation and assembly of fibrils has provided a number of targets for therapeutic intervention. Solid-state NMR, hydrogen/deuterium exchange and mutagenesis strategies have been used to pro... |
|
|
Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology.
J. Mol. Med. 85(6) , 603-11, (2007) Inositol is a simple polyol with eight naturally occurring stereoisomers. myo-Inositol, D-chiro- and epi-inositol have been examined as potential therapeutic agents for various diseases, with favorable results, but treatment with scyllo-inositol has not been ... |
|
|
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.
Ann. Neurol. 60(6) , 668-76, (2006) Despite progress in defining a pathogenic role for amyloid beta protein (Abeta) in Alzheimer's disease, orally bioavailable compounds that prevent its effects on hippocampal synaptic plasticity and cognitive function have not yet emerged. A particularly attra... |
|
|
Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease.
Biochim. Biophys. Acta 1822(10) , 1629-37, (2012) scyllo-Inositol (SI) is an endogenous inositol stereoisomer known to inhibit aggregation and fibril formation of the amyloid-beta peptide (Aβ). Human clinical trials using SI to treat Alzheimer disease (AD) patients have shown potential benefits. In light of ... |