3-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮
![3-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮结构式](https://image.chemsrc.com/caspic/337/75444-65-4.png)
3-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮结构式
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常用名 | 3-(2-(4-(4-氟苯甲酰基)哌啶-1-基)乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮 | 英文名 | Pirenperone |
|---|---|---|---|---|
| CAS号 | 75444-65-4 | 分子量 | 393.45 | |
| 密度 | 1.26g/cm3 | 沸点 | 556.3ºC at 760 mmHg | |
| 分子式 | C23H24FN3O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 290.2ºC |
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5-HT inhibits spontaneous contractility of isolated sheep mesenteric lymphatics via activation of 5-HT(4) receptors.
Microvasc. Res. 60(3) , 261-8, (2000) Spontaneous isometric contractions were measured in rings of sheep mesenteric lymphatic vessels in vitro. 5-Hydroxytryptamine (5-HT) produced a concentration-dependent decrease in spontaneous contraction frequency and force which was not antagonised by either... |
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Monoamine systems in the discriminative effects of spiradoline, a kappa-opioid agonist.
Pharmacol. Biochem. Behav. 47(3) , 575-8, (1994) The results of studies on mice indicate that the antinociceptive effects of kappa-opioid agonists are due, in part, to activation of the 5-HT2 type of serotonin receptor. One objective of this study was to determine if the discriminative effects of spiradolin... |
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Visual recognition memory in squirrel monkeys: effects of serotonin antagonists on baseline and hypoxia-induced performance deficits.
Pharmacol. Biochem. Behav. 39(4) , 991-6, (1991) Cognitive deficits resulting from neuropathological brain changes such as Alzheimer's Disease or normal aging are most likely due to alterations in multiple neurotransmitter systems. While the majority of preclinical studies have focused on the effects of ace... |
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The discriminative stimulus properties of EGb 761, an extract of Ginkgo biloba.
Pharmacol. Biochem. Behav. 62(3) , 543-7, (1999) Stimulus control was established in a group of nine rats using a dose of EGb 761 of 10 mg/kg, administered i.p., 15 min before training. A two-lever operant task using a fixed-ratio 10 schedule of sweetened milk reinforcement was used. Based upon a criterion ... |
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Anti-serotonin action in combination with noradrenaline-stimulating action is important for inhibiting muricide in midbrain raphe-lesioned rats.
Neuropharmacology 27(2) , 123-7, (1988) The present study was designed to examine the possible involvement of both an anti-serotonin action and a catecholamine-stimulating action in the mechanism of the inhibition of the muricide in rats with lesions of the midbrain raphe. Serotonin antagonists, su... |
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Maturational age affects pirenperone dose-response pattern.
Gen. Pharmacol. 18(3) , 225-7, (1987) The effects of the 5-HT2 antagonist pirenperone on temperature preference were observed 1 hr after injection in mice aged 3, 5 and 7 days and at doses of 0.16, 0.48 and 1.6 mg/kg body weight. Although all 3 doses produced significant decreases in preferred te... |
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Antinociceptive effects of the kappa opioid, U50,488: lack of modulation by 5-HT2 antagonists.
Psychopharmacology 112(1) , 116-20, (1993) The kappa opioid, U50,488, was examined alone and in combination with the 5HT2 antagonists, ketanserin, pirenperone and LY 53857. Squirrel monkeys responded under a shock titration procedure in which shock intensity increased every 15 s from 0.01 to 2.0 mA in... |
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Investigation of the mechanism by which ketanserin prolongs the duration of the cardiac action potential.
J. Cardiovasc. Pharmacol. 26(5) , 803-9, (1995) Action potential duration (APD) lengthening is believed to underlie the cardiac arrhythmogenicity of ketanserin, a serotonin (5-HT)2A/2C receptor antagonist. We wished to determine (a) whether this activity involves blockade of 5-HT2A/2C receptors and (b) the... |
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Inhibitory action of alpha-melanocyte stimulating hormone on lordosis in rats: possible involvement of serotonin.
Pharmacol. Biochem. Behav. 30(1) , 37-43, (1988) Alpha-melanocyte stimulating hormone (MSH) has been found to exert a short- and a long-term inhibitory action on lordosis. The present series of experiments examined the possibility that these effects are mediated by MSH-induced alterations in activity at ser... |
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Reduction in opioid and non-opioid forms of swim analgesia by 5-HT2 receptor antagonists.
Brain Res. 500(1-2) , 231-40, (1989) Acute exposure to continuous (CCWS) or intermittent (ICWS) cold-water swims elicits non-opioid and opioid forms of analgesia respectively. Intrathecal administration of methysergide blocks ICWS, but not CCWS analgesia. The present study evaluated the role of ... |