抗坏血酸
抗坏血酸结构式
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常用名 | 抗坏血酸 | 英文名 | Ascorbic acid |
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| CAS号 | 50-81-7 | 分子量 | 176.124 | |
| 密度 | 2.0±0.1 g/cm3 | 沸点 | 552.7±50.0 °C at 760 mmHg | |
| 分子式 | C6H8O6 | 熔点 | 190-194 °C (dec.) | |
| MSDS | 中文版 美版 | 闪点 | 238.2±23.6 °C |
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Comparative in vitro study on magnetic iron oxide nanoparticles for MRI tracking of adipose tissue-derived progenitor cells.
PLoS ONE 9(9) , e108055, (2014) Magnetic resonance imaging (MRI) using measurement of the transverse relaxation time (R2*) is to be considered as a promising approach for cell tracking experiments to evaluate the fate of transplanted progenitor cells and develop successful cell therapies fo... |
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DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.
Toxicol. Sci. 143(1) , 54-63, (2014) Hexavalent chromium is a human respiratory carcinogen that undergoes intracellular activation in vivo primarily via reduction with ascorbate. Replication of Cr-adducted DNA triggers mismatch repair that generates toxic DNA double-strand breaks (DSBs) as secon... |
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Hypoxia reduces MAX expression in endothelial cells by unproductive splicing.
FEBS Lett. 588(24) , 4784-90, (2014) The MYC-MAX-MXD network is involved in the regulation of cell differentiation and proliferation. Hypoxia affects the expression levels of several members of this network, but changes specific to MAX expression have so far not been shown. We found that in endo... |
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Proteolysis of decellularized extracellular matrices results in loss of fibronectin and cell binding activity.
Biochem. Biophys. Res. Commun. 459(2) , 246-51, (2015) Excessive inflammation in the chronic wound bed is believed to result in increased fibronectin (FN) proteolysis and poor tissue repair. However, FN fragments can prime the immune response and result in higher protease levels. The reciprocity between FN proteo... |
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Flow perfusion co-culture of human mesenchymal stem cells and endothelial cells on biodegradable polymer scaffolds.
Ann. Biomed. Eng. 42(7) , 1381-90, (2014) In this study, we investigated the effect of flow perfusion culture on the mineralization of co-cultures of human umbilical vein endothelial cells (HUVECs) and human mesenchymal stem cells (hMSCs). Osteogenically precultured hMSCs were seeded onto electrospun... |
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Coculture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells on strontium-doped calcium polyphosphate scaffolds to generate vascularized engineered bone.
Tissue Eng. Part A 21(5-6) , 948-59, (2015) Vascularization of engineered bone tissue is critical for ensuring its survival after implantation and it is the primary factor limiting its clinical use. A promising approach is to prevascularize bone grafts in vitro using endothelial progenitor cells (EPC) ... |
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4-Hydroxyisoleucine production of recombinant Corynebacterium glutamicum ssp. lactofermentum under optimal corn steep liquor limitation.
Appl. Microbiol. Biotechnol. 99(9) , 3851-63, (2015) 4-Hydroxyisoleucine (4-HIL) is a nonproteinogenic amino acid that exhibits insulinotropic biological activity. Here, L-isoleucine dioxygenase gene (ido) derived from Bacillus thuringiensis YBT-1520 was cloned and expressed in an L-isoleucine-producing strain,... |
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Vegetables' juice influences polyol pathway by multiple mechanisms in favour of reducing development of oxidative stress and resultant diabetic complications.
Pharmacogn. Mag. 10(Suppl 2) , S383-91, (2014) Hyperglycemia induced generation of free radicals and consequent development of oxidative stress by polyol pathway is one of the crucial mechanisms stirring up development of diabetic complications. We evaluated influence of ten vegetables' juice on polyol pa... |
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Matrix stiffening and β1 integrin drive subtype-specific fibroblast accumulation in lung cancer.
Mol. Cancer Res. 13(1) , 161-73, (2015) The crucial role of tumor-associated fibroblasts (TAF) in cancer progression is now clear in non-small cell lung cancer (NSCLC). However, therapies against TAFs are limited due to a lack of understanding in the subtype-specific mechanisms underlying their acc... |
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Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage.
Leuk. Lymphoma 56(3) , 739-47, (2015) The tumor suppressor p53 is often mutated in human cancers. Restoring its antitumor activity has been shown to be a promising therapeutic approach for cancer treatment. Here we analyzed the activity and mechanism of a p53 reactivator, ellipticine, in a cellul... |