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溴夫定

溴夫定结构式
溴夫定结构式
品牌特惠专场
常用名 溴夫定 英文名 Brivudine
CAS号 69304-47-8 分子量 333.135
密度 1.9±0.1 g/cm3 沸点 382.9ºC at 760 mmHg
分子式 C11H13BrN2O5 熔点 165ºC
MSDS 美版 闪点 185.4ºC

Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues.

Biochem. J. 445(1) , 113-23, (2012)

In the present paper we demonstrate that the cytostatic and antiviral activity of pyrimidine nucleoside analogues is markedly decreased by a Mycoplasma hyorhinis infection and show that the phosphorolytic activity of the mycoplasmas is responsible for this. S...

Synthesis of nucleoside-based antiviral drugs in ionic liquids.

Bioorg. Med. Chem. Lett. 18(20) , 5640-2, (2008)

Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of solubility and reaction medium as compared to conventional ...

Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts.

Nucleosides Nucleotides Nucleic Acids 29(1) , 1-13, (2010)

Thymidine kinase 2 (TK2) is a mitochondrial deoxyribonucleoside kinase that phosphorylates several nucleoside analogs used in anti-viral and anti-cancer therapy. A fibroblast cell line with decreased TK2 activity was investigated in order to obtain insights i...

Interaction between capecitabine and brivudin in a patient with breast cancer.

Nat. Rev. Clin. Oncol. 7(1) , 55-8, (2010)

A 66-year-old woman with metastatic mammary carcinoma, who was being treated with capecitabine, contracted a herpes zoster infection that was treated with the antiviral drug brivudin. A drug-drug interaction between brivudin and capecitabine caused medullar a...

Phenotypic and genetic characterization of varicella-zoster virus mutants resistant to acyclovir, brivudine and/or foscarnet.

Med. Microbiol. Immunol. 200(3) , 193-202, (2011)

The treatment of varicella-zoster virus (VZV) reactivation is based on nucleoside analogues acyclovir (ACV) and bromevinyldeoxyuridine (BVdU) and a phosphonic acid derivative (PFA). Drug-resistant mutants of 3 wild-type (WT) VZV strains were obtained by expos...

5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts.

Nucleosides Nucleotides Nucleic Acids 27(6) , 858-62, (2008)

Mitochondrial thymidine kinase (TK2) is responsible for phosphorylation of thymidine and deoxycytidine and plays a crucial role in mitochondrial DNA precursor synthesis. TK2 is expressed in all tissues at low levels complicating accurate determinations, espec...

Fatal drug-drug interaction of brivudine and capecitabine.

Acta Oncol. 48(4) , 631-3, (2009)

Perineal muco-cutaneous herpes zoster treated with brivudin.

J. Dermatolog. Treat. 19(4) , 255-6, (2008)

Herpes zoster results from the reactivation of latent varicella-zoster virus (VZV) from the dorsal root ganglion of sensory nerves. It is rarely described in the pediatric population. We report the case of an 8-year-old immunocompetent boy with a painful lumb...

Brivudin induced delirium: a case report.

J. Chemother. 24(4) , 229-30, (2012)

Brivudin is an oral antiviral agent used to treat herpes zoster infections. Common side effects of brivudin include nausea and headache. This report describes delirium in a patient who used brivudin for herpes zoster treatment, which consequently remitted aft...

Potent anticancer effects of lentivirus encoding a Drosophila melanogaster deoxyribonucleoside kinase mutant combined with brivudine.

Asian Pac. J. Cancer Prev. 13(5) , 2121-7, (2012)

Deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) mutants have been reported to exert suicide gene effects in combined gene/chemotherapy of cancer. Here, we aimed to further evaluate the capacity of the mutanted enzyme and its potential for inhib...