氯沙坦钾结构式
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常用名 | 氯沙坦钾 | 英文名 | Losartan potassium |
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| CAS号 | 124750-99-8 | 分子量 | 461.001 | |
| 密度 | 0.986 g/mL at 25 °C(lit.) | 沸点 | 134 °C(lit.) | |
| 分子式 | C22H22ClKN6O | 熔点 | −69 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 76 °F |
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Synthesis and evaluation of the novel 2-[¹⁸F]fluoro-3-propoxy-triazole-pyridine-substituted losartan for imaging AT₁ receptors.
Bioorg. Med. Chem. 22(15) , 3931-7, (2014) The 2-[(18)F]fluoro-3-pent-4-yn-1-yloxypyridine ([(18)F]FPyKYNE) analog of the potent non-peptide angiotensin II type 1 receptor (AT1R) blocker losartan was produced via click chemistry linking [(18)F]FPyKYNE to azide-modified tetrazole-protected losartan fol... |
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Role of 5-HT7 receptors in the inhibition of the vasodepressor sensory CGRPergic outflow in pithed rats
Vascul. Pharmacol. 63(1) , 4-12, (2014) The role of calcitonin gene-related peptide (CGRP) in the modulation of vascular tone has been widely documented. Indeed, electrical stimulation of the perivascular sensory outflow in pithed rats induces vasodepressor responses by activation of CGRP receptors... |
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Simultaneous determination of polar pharmaceuticals and personal care products in biological organs and tissues.
J. Chromatogr. A. 1355 , 193-205, (2014) In the present study, a sensitive and accurate isotope dilution method was developed for the simultaneous determination of 17 polar pharmaceutical and personal care product (PPCP) residues (logKow=1.40-5.74), including 14 pharmaceuticals and 3 personal care p... |
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Determination of losartan potassium, quinapril hydrochloride and hydrochlorothiazide in pharmaceutical preparations using derivative spectrophotometry and chromatographic-densitometric method.
Acta Pol. Pharm. 70(6) , 967-76, (2013) Two methods, spectrophotometric and chromatographic-densitometric ones, were developed for determination of losartan potassium, quinapril hydrochloride and hydrochlorothiazide in pharmaceutical preparations. Spectrophotometric method involved derivative spect... |
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Intracerebroventricular infusion of the (Pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate-salt-induced hypertension.
Hypertension 65(2) , 352-61, (2015) We previously reported that binding of prorenin to the (pro)renin receptor (PRR) plays a major role in brain angiotensin II formation and the development of deoxycorticosterone acetate (DOCA)-salt hypertension. Here, we designed and developed an antagonistic ... |
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Chronological effects of rifampicin discontinuation on cytochrome P450 activity in healthy Japanese volunteers, using the cocktail method.
Clin. Pharmacol. Ther. 94(6) , 702-8, (2013) Cytochrome P450 (CYP) 1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A are major factors involved in the metabolism of clinically prescribed drugs. Because the time course after drug treatment discontinuation has received little attention, we aimed to clarify the chro... |
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A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 305(10) , R1133-40, (2013) A number of 8-substituted chrysin analogs have been prepared and evaluated for their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E(2) and iNOS-mediated NO production. Analogs were prepared via Suzuki-Miyaura C-C cross coupling reaction o... |
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Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multiligand endocytic receptor megalin.
Am. J. Physiol. Renal Physiol. 307(2) , F222-33, (2014) The present study tested the hypothesis that the multiligand endocytic receptor megalin is partially involved in the uptake of ANG II and downstream signaling responses in mouse proximal tubule cells (mPCT) by interacting with AT1a receptors. mPCT cells of wi... |
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Recurrent angioedema after naproxen use in a patient stabilized with losartan.
Ann. Allergy Asthma Immunol. 113(6) , 666-7, (2014)
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Losartan prevents acquired epilepsy via TGF-β signaling suppression.
Ann. Neurol. 75(6) , 864-75, (2014) Acquired epilepsy is frequently associated with structural lesions after trauma, stroke, and infections. Although seizures are often difficult to treat, there is no clinically applicable strategy to prevent the development of epilepsy in patients at risk. We ... |