L-谷胱甘肽(氧化型)
L-谷胱甘肽(氧化型)结构式
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常用名 | L-谷胱甘肽(氧化型) | 英文名 | L(-)-Glutathione |
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| CAS号 | 27025-41-8 | 分子量 | 612.631 | |
| 密度 | 1.7±0.1 g/cm3 | 沸点 | 976.3±75.0 °C at 760 mmHg | |
| 分子式 | C20H32N6O12S2 | 熔点 | 178 °C (dec.)(lit.) | |
| MSDS | 美版 | 闪点 | 544.3±37.1 °C |
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Long-chain fatty acid analogues suppress breast tumorigenesis and progression.
Cancer Res. 74(23) , 6991-7002, (2014) Obesity and type 2 diabetes (T2D) are associated with increased breast cancer incidence and mortality, whereas carbohydrate-restricted ketogenic diets ameliorate T2D and suppress breast cancer. These observations suggest an inherent efficacy of nonesterified ... |
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Ratios of biliary glutathione disulfide (GSSG) to glutathione (GSH): a potential index to screen drug-induced hepatic oxidative stress in rats and mice.
Anal. Bioanal. Chem 405(8) , 2635-42, (2013) Hepatotoxicity of drug candidates is one of the major concerns in drug screening in early drug discovery. Detection of hepatic oxidative stress can be an early indicator of hepatotoxicity and benefits drug selection. The glutathione (GSH) and glutathione disu... |
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Cardiovascular disease-related parameters and oxidative stress in SHROB rats, a model for metabolic syndrome.
PLoS ONE 9(8) , e104637, (2014) SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this model is limited. Here, we extensively evaluate parameters rela... |
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The traditional drug Gongjin-Dan ameliorates chronic fatigue in a forced-stress mouse exercise model.
J. Ethnopharmacol. 168 , 268-78, (2015) Gongjin-Dan is a representative traditional Oriental medicine herbal drug that has been used to treat chronic fatigue symptoms for several hundred years. We evaluated the anti-fatigue effects of Gongjin-Dan and the underlying mechanisms in a chronic forced ex... |
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Interleukin-1β protects astrocytes against oxidant-induced injury via an NF-κB-dependent upregulation of glutathione synthesis.
Glia 63 , 1568-80, (2015) Astrocytes produce and export the antioxidant glutathione (GSH). Previously, we found that interleukin-1β (IL-1β) enhanced the expression of astrocyte system xc (-) , the transporter that delivers the rate-limiting substrate for GSH synthesis-cyst(e)ine. Here... |
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A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3.
Mol. Cell. Biol. 35 , 3646-56, (2015) Increased production of mitochondrion-derived reactive oxygen species (ROS) is characteristic of a metabolic shift observed during malignant transformation. While the exact sources and roles of ROS in tumorigenesis remain to be defined, it has become clear th... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Effects of carcinogenic versus non-carcinogenic AHR-active PAHs and their mixtures: lessons from ecological relevance.
Environ. Res. 138 , 101-11, (2015) Polycyclic aromatic hydrocarbons (PAHs) are priority environmental mutagens and carcinogens that occur in the aquatic environment as mixtures rather than the individual compounds for which guidelines are issued. The present work aimed at understanding the int... |
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Structure-activity relationship analysis of curcumin analogues on anti-influenza virus activity.
FEBS J. 280(22) , 5829-40, (2013) Curcumin (Cur) is a commonly used colouring agent and spice in food. Previously, we reported that Cur inhibits type A influenza virus (IAV) infection by interfering with viral haemagglutination (HA) activity. To search for a stable Cur analogue with potent an... |
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A colorimetric sensor array for detection and discrimination of biothiols based on aggregation of gold nanoparticles.
Anal. Chim. Acta 882 , 58-67, (2015) Developments of sensitive, rapid, and cheap systems for identification of a wide range of biomolecules have been recognized as a critical need in the biology field. Here, we introduce a simple colorimetric sensor array for detection of biological thiols, base... |