二(2-羟乙基)亚氨基三(羟甲基)甲烷
二(2-羟乙基)亚氨基三(羟甲基)甲烷结构式
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常用名 | 二(2-羟乙基)亚氨基三(羟甲基)甲烷 | 英文名 | Bis-tris methane |
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| CAS号 | 6976-37-0 | 分子量 | 209.240 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 466.2±40.0 °C at 760 mmHg | |
| 分子式 | C8H19NO5 | 熔点 | 104 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 288.0±26.0 °C |
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Salicylic acid signaling controls the maturation and localization of the arabidopsis defense protein ACCELERATED CELL DEATH6.
Mol. Plant 7(8) , 1365-83, (2014) ACCELERATED CELL DEATH6 (ACD6) is a multipass membrane protein with an ankyrin domain that acts in a positive feedback loop with the defense signal salicylic acid (SA). This study implemented biochemical approaches to infer changes in ACD6 complexes and local... |
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Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.
J. Clin. Invest. 125(2) , 607-20, (2015) Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited nephropathy responsible for 4%-10% of end-stage renal disease cases. Mutations in the genes encoding polycystin-1 (PC1, PKD1) or polycystin-2 (PC2, PKD2) cause ADPKD, and PKD1 mutation... |
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A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.
Angiogenesis 18(2) , 209-17, (2015) Activin receptor-like kinase 1 (ALK1, encoded by the gene ACVRL1) is a type I BMP/TGF-β receptor that mediates signalling in endothelial cells via phosphorylation of SMAD1/5/8. During angiogenesis, sprouting endothelial cells specialise into tip cells and sta... |
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The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine.
PLoS Genet. 10(9) , e1004659, (2014) The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and biological stresses p38 kinases phosphorylate various subst... |
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Progressive accumulation of activated ERK2 within highly stable ORF45-containing nuclear complexes promotes lytic gammaherpesvirus infection.
PLoS Pathog. 10(4) , e1004066, (2014) De novo infection with the gammaherpesvirus Rhesus monkey rhadinovirus (RRV), a close homolog of the human oncogenic pathogen, Kaposi's sarcoma-associated herpesvirus (KSHV), led to persistent activation of the MEK/ERK pathway and increasing nuclear accumulat... |
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Methionine oxidation accelerates the aggregation and enhances the neurotoxicity of the D178N variant of the human prion protein.
Biochim. Biophys. Acta 1842(12 Pt A) , 2345-56, (2014) The D178N mutation of the prion protein (PrP) results in the hereditary prion disease fatal familial insomnia (FFI). Little is known regarding the effects of methionine oxidation on the pathogenesis of D178N-associated FFI. In the present study, we found that... |
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Stability of collapse lyophilized influenza vaccine formulations.
Int. J. Pharm. 483(1-2) , 131-41, (2015) A clear limitation of many liquid vaccines is the obligatory cold-chain distribution system. Therefore, distribution of a dried vaccine formulation may be beneficial in terms of vaccine stability, handling and transport. Collapse freeze-drying is a process wh... |
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RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62.
Biochem. Biophys. Res. Commun. 456(1) , 298-304, (2014) RIPK3 is a key molecule for necroptosis, initially characterized by necrotic cell death morphology and the activation of autophagy. Cell death and autophagic signaling are believed to tightly regulate each other. However, the associated recruitment of signali... |
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Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner.
Nat. Commun. 5 , 5637, (2014) Mcl-1 is a unique Bcl-2 family member that plays crucial roles in apoptosis. Apoptosis-unrelated functions of Mcl-1 are however emerging, further justifying its tight regulation. Here we unravel a novel mechanism of Mcl-1 regulation mediated by the haplo-insu... |
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Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
PLoS Genet. 10(11) , e1004741, (2014) Aggregation of alpha-synuclein (ASYN) in Lewy bodies and Lewy neurites is the typical pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. Furthermore, mutations in the gene encoding for ASYN are associated with familial and sporadic... |