三(羟甲基)氨基甲烷
三(羟甲基)氨基甲烷结构式
|
常用名 | 三(羟甲基)氨基甲烷 | 英文名 | Trometamol |
|---|---|---|---|---|
| CAS号 | 77-86-1 | 分子量 | 121.135 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 357.0±37.0 °C at 760 mmHg | |
| 分子式 | C4H11NO3 | 熔点 | 167-172 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 169.7±26.5 °C |
|
Methionine oxidation accelerates the aggregation and enhances the neurotoxicity of the D178N variant of the human prion protein.
Biochim. Biophys. Acta 1842(12 Pt A) , 2345-56, (2014) The D178N mutation of the prion protein (PrP) results in the hereditary prion disease fatal familial insomnia (FFI). Little is known regarding the effects of methionine oxidation on the pathogenesis of D178N-associated FFI. In the present study, we found that... |
|
|
HBP1 promoter methylation augments the oncogenic β-catenin to correlate with prognosis in NSCLC.
J. Cell. Mol. Med. 18(9) , 1752-61, (2014) β-catenin nuclear accumulation is frequently identified in human non-small cell lung cancer (NSCLC). The HMG-box transcription factor 1 (HBP1) is a known repressor of β-catenin transactivation. However, the role of HBP1 in relation to β-catenin nuclear accumu... |
|
|
Use of an enzyme-assisted method to improve protein extraction from olive leaves.
Food Chem. 169 , 28-33, (2014) The improvement of protein extraction from olive leaves using an enzyme-assisted protocol has been investigated. Using a cellulase enzyme (Celluclast® 1.5L), different parameters that affect the extraction process, such as the influence and amount of organic ... |
|
|
High-throughput electrophoretic mobility shift assays for quantitative analysis of molecular binding reactions.
Anal. Chem. 86(20) , 10357-64, (2014) We describe a platform for high-throughput electrophoretic mobility shift assays (EMSAs) for identification and characterization of molecular binding reactions. A photopatterned free-standing polyacrylamide gel array comprised of 8 mm-scale polyacrylamide gel... |
|
|
MeCP2 deficiency is associated with reduced levels of tubulin acetylation and can be restored using HDAC6 inhibitors.
J. Mol. Med. 93(1) , 63-72, (2015) Rett syndrome (RTT) is a severe neurodevelopmental disorder, predominantly caused by loss of function mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene. Despite the genetic cause being known in the majority of cases, the pathophysiology of t... |
|
|
Stability of collapse lyophilized influenza vaccine formulations.
Int. J. Pharm. 483(1-2) , 131-41, (2015) A clear limitation of many liquid vaccines is the obligatory cold-chain distribution system. Therefore, distribution of a dried vaccine formulation may be beneficial in terms of vaccine stability, handling and transport. Collapse freeze-drying is a process wh... |
|
|
Polyoxometalates--potent and selective ecto-nucleotidase inhibitors.
Biochem. Pharmacol. 93(2) , 171-81, (2015) Polyoxometalates (POMs) are inorganic cluster metal complexes that possess versatile biological activities, including antibacterial, anticancer, antidiabetic, and antiviral effects. Their mechanisms of action at the molecular level are largely unknown. Howeve... |
|
|
Glucose recognition proteins for glucose sensing at physiological concentrations and temperatures.
ACS Chem. Biol. 9(7) , 1595-602, (2014) Advancements in biotechnology have allowed for the preparation of designer proteins with a wide spectrum of unprecedented chemical and physical properties. A variety of chemical and genetic methods can be employed to tailor the protein's properties, including... |
|
|
Purification and characterization of a DNA-binding recombinant PREP1:PBX1 complex.
PLoS ONE 10(4) , e0125789, (2015) Human PREP1 and PBX1 are homeodomain transcriptional factors, whose biochemical and structural characterization has not yet been fully described. Expression of full-length recombinant PREP1 (47.6 kDa) and PBX1 (46.6 kDa) in E. coli is difficult because of poo... |
|
|
Assessing glucose uptake through the yeast hexose transporter 1 (Hxt1).
PLoS ONE 10(3) , e0121985, (2015) The transport of glucose across the plasma membrane is mediated by members of the glucose transporter family. In this study, we investigated glucose uptake through the yeast hexose transporter 1 (Hxt1) by measuring incorporation of 2-NBDG, a non-metabolizable... |