5-甲氧基吲哚-3-乙醇

Biochem. Biophys. Res. Commun. 282(5) , 1229-36, (2001)

Site-directed mutation of serine 110 (Ser(3.35)) and serine 114 (Ser(3.39)) in the human melatonin MT(1) receptor to alanine residues reduced ligand binding affinities of seven known melatonin receptor agonists and partial agonists by 3- to 15-fold. These mut...

Gen. Comp. Endocrinol. 120(2) , 212-9, (2000)

The chick pineal gland rhythmically synthesizes two 5-methoxyindoles, melatonin and 5-methoxytryptophol. These rhythms are circadian in nature and have opposite phases. The aim of this study was to determine the effects of cycloheximide, a protein synthesis i...

J. Cell. Biochem. 76(4) , 651-7, (2000)

Lipid peroxidation is a degenerative chain reaction in biological membranes that may be initiated by exposure to free radicals. This process is associated with changes in the membrane fluidity and loss of several cell membrane-dependent functions. 5-methoxytr...

Gen. Comp. Endocrinol. 144(1) , 67-77, (2005)

This study describes the diel rhythms in several indoleamines, melatonin, and related 5-methoxyindoles in the pineal organ of rainbow trout in vivo. In addition, the effect of different photoperiod conditions was evaluated. Melatonin levels displayed clear da...

J. Biol. Regul. Homeost. Agents 11(3) , 119-22, (1997)

Despite several years of experimental observations, the clinical application of the neuroimmunomodulation is still at the beginning. The pineal gland plays a main role in mediating the link between psychoneuroendocrine and immune systems. Melatonin (MLT), whi...

Ann. N. Y. Acad. Sci. 917 , 560-7, (2000)

Lymphocyte number still remains one of the most important immune parameters predicting the prognosis of advanced cancer patients. IL-2 and IL-12 are the main antitumor cytokines in humans, and their effect is modulated by the neuroendocrine system, mainly by ...

Gen. Comp. Endocrinol. 134(3) , 296-302, (2003)

The goose pineal gland rhythmically produces two 5-methoxyindole compounds, namely melatonin and 5-methoxytryptophol. Melatonin concentrations were high at night and low during the day, while in contrast 5-methoxytryptophol levels were markedly higher during ...

J. Physiol. Pharmacol. 62(6) , 677-83, (2011)

Bacterial lipopolysaccharide (LPS) causes lipid peroxidation (LPO). We have found that LPS induces LPO in tissue homogenates in vitro in a concentration-dependent manner, the concentration of 400 μg/ml demonstrating the most efficient lipid damaging effect. A...

Brain Res. Bull. 46(5) , 417-22, (1998)

It has been shown that 5-hydroxytryptamine and melatonin, an indoleamine for which 5-hydroxytryptamine is a precursor, influence the release of vasopressin and oxytocin from the rat hypothalamus both in vivo and in vitro. The oral administration of melatonin ...

Neurosci. Lett. 251(1) , 33-6, (1998)

5-Methoxytryptophol (5-ML) rhythms were studied in the pineal glands of chicks which were adapted to three different lighting conditions: 12 h light: 12 h dark (LD), constant darkness (DD) and continuous light (LL). Pineal glands of chicks kept under LD condi...