N-苯甲酰基-beta-丙氨酸
N-苯甲酰基-beta-丙氨酸结构式
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常用名 | N-苯甲酰基-beta-丙氨酸 | 英文名 | Betamipron |
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| CAS号 | 3440-28-6 | 分子量 | 193.19900 | |
| 密度 | 1.227 g/cm3 | 沸点 | 469.2ºC at 760 mmHg | |
| 分子式 | C10H11NO3 | 熔点 | 132 °C | |
| MSDS | N/A | 闪点 | 237.6ºC |
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Reaction of Pseudomonas fluorescens kynureninase with beta-benzoyl-L-alanine: detection of a new reaction intermediate and a change in rate-determining step.
Biochemistry 43(11) , 3230-7, (2004) Beta-benzoyl-DL-alanine was synthesized from alpha-bromoacetophenone and diethyl acetamidomalonate. The racemic amino acid was resolved by carboxypeptidase A-catalyzed hydrolysis of the N-trifluoroacetyl derivative. Beta-benzoyl-L-alanine is a good substrate ... |
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Thermodynamic quantitative structure-activity relationship analysis for enzyme-ligand interactions in aqueous phosphate buffer and organic solvent.
Bioorg. Med. Chem. 9(8) , 1951-5, (2001) Thermodynamic quantitative structure-activity relationships (QSAR) for chymotrypsin-ligand binding is developed, and the results are compared for the effects of organic solvent on the substrate specificity of the enzymes to those in aqueous phosphate buffer. ... |
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Nephroprotective effect of betamipron on a new carbapenem, DA-1131, in rabbits.
Biopharm. Drug Dispos. 20(3) , 125-9, (1999) The nephroprotective effect of betamipron (200 mg/kg) was evaluated after intravenous administration of a high dose of DA-1131 (200 mg/kg) to rabbits. Extensive tubular necrosis was observed without betamipron but the necrosis was not observed with betamipron... |
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Structural effects of N-aromatic acyl-amino acid conjugates on their deconjugation in the cecal contents of rats: implication in design of a colon-specific prodrug with controlled conversion rate at the target site.
Biopharm. Drug Dispos. 32(6) , 343-54, (2011) N-aromatic acyl-amino acid conjugates possess a colon-targeted property, implying that such conjugates are stable and are not absorbable until reaching the large intestine in which they are microbially converted (hydrolysed) to the parent drugs that are thera... |
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Protective effects of N-benzoyl amino acids on cisplatin nephrotoxicity in rats.
Biol. Pharm. Bull. 19(11) , 1451-6, (1996) The protective effects of N-benzoyl amino acids (NAAs) and piperacillin (PIP), anionic transport inhibitors, against the nephrotoxicity of cisplatin were examined in rats. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with i.p. NAAs o... |
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Effects of betamipron on cisplatin nephrotoxicity and its pharmacokinetics in rats.
Biol. Pharm. Bull. 20(4) , 386-91, (1997) The protective effects of betamipron (BP, N-benzoyl-beta-alanine) on the nephrotoxicity of cisplatin were examined as indicated by body weight gain, ratio of kidney weight to body weight, blood urea nitrogen and serum creatinine levels in tumor-bearing rats. ... |
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Population pharmacokinetic analysis of panipenem/betamipron in patients with various degrees of renal function.
Chemotherapy 52(5) , 245-53, (2006) Although plasma concentrations of panipenem were elevated and the risk of adverse events would increase in patients with renal impairment, a precise dosage regimen for patients with renal impairment has not been established.Population pharmacokinetic analyses... |
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Protective effect of N-benzoyl-beta-alanine against cisplatin nephrotoxicity in rats.
Ren. Fail. 18(2) , 225-40, (1996) Prophylactic effects of N-benzoyl-beta-alanine (betamipron, BP), one of a series of N-acyl amino acids, were examined against cisplatin-induced nephrotoxicity. Male Wistar rats were injected i.p. with 6 mg/kg of cisplatin combined with an i.p. BP dose given a... |
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Protective effects of betamipron on renal toxicity during repeated cisplatin administration in rats and protective mechanism.
Ren. Fail. 20(1) , 27-38, (1998) The protective effects of betamipron (BP, N-benzoyl-beta-alanine) against nephrotoxicity induced by repeated cisplatin injections were examined. The ratio of the kidney weight to body weight and the lipid peroxide level after treatment with cisplatin plus BP ... |
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Betamipron reduces cisplatin nephrotoxicity in rodents without modifying its antileukemic activity in mice.
Ren. Fail. 19(3) , 425-38, (1997) Protective effects of betamipron (BP, N-benzoyl-beta-alanine), one of a series of N-acyl amino acids, on cisplatin-induced nephrotoxicity were examined. Since the damage observed in the kidney is localized to the proximal tubule cells, we investigated the inf... |