L-蛋氨酸砜
L-蛋氨酸砜结构式
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常用名 | L-蛋氨酸砜 | 英文名 | (2S)-2-Amino-4-(Methylsulfonyl)-Butanoic Acid |
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| CAS号 | 7314-32-1 | 分子量 | 181.21 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 450.5±40.0 °C at 760 mmHg | |
| 分子式 | C5H11NO4S | 熔点 | ~275 °C (dec.) | |
| MSDS | 中文版 美版 | 闪点 | 226.3±27.3 °C |
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In Salmonella enterica, the Gcn5-related acetyltransferase MddA (formerly YncA) acetylates methionine sulfoximine and methionine sulfone, blocking their toxic effects.
J. Bacteriol. 197(2) , 314-25, (2015) Protein and small-molecule acylation reactions are widespread in nature. Many of the enzymes catalyzing acylation reactions belong to the Gcn5-related N-acetyltransferase (GNAT; PF00583) family, named after the yeast Gcn5 protein. The genome of Salmonella ent... |
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Copper(II) complexes of neurokinin A with point mutation (S5A) and products of copper-catalyzed oxidation; role of serine residue in peptides containing neurokinin A sequence.
J. Inorg. Biochem. 121 , 1-9, (2013) A potentiometric, spectroscopic (UV-visible, CD and EPR) and electrospray ionization mass spectrometric (ESI-MS) study of Cu(II) binding to the neurokinin A with point mutation (S5A) (ANKA), His-Lys-Thr-Asp-Ala(5)-Phe-Val-Gly-Leu-Met-NH2 and its N-acethyl der... |
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Metabolomics study of hepatocellular carcinoma: discovery and validation of serum potential biomarkers by using capillary electrophoresis-mass spectrometry.
J. Proteome Res. 13(7) , 3420-31, (2014) Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. The lack of effective screening methods for early diagnosis has been a longstanding bottleneck to improve the survival rate. In the present study, a capillary electrophoresis-time-of-fligh... |
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Analysis of methionine oxides and nitrogen-transporting amino acids in chilled and acclimated maize seedlings.
Amino Acids 33(4) , 607-13, (2007) In maize seedlings, chilling causes a reduction of glutamine synthetase (GS) activity, while acclimation protects GS (manuscript submitted). Since ROS can oxidize both protein-bound and free Met to methionine sulfoxide (MSO) and further to methionine sulfone ... |
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Studies on the utilization of methionine sulfoxide and methionine sulfone by rumen microorganisms in vitro.
Amino Acids 24(1-2) , 135-9, (2003) An in vitro experiment was conducted to test the ability of mixed rumen bacteria (B), protozoa (P), and their mixture (BP) to utilize the oxidized forms of methionine (Met) e.g., methionine sulfoxide (MSO), methionine sulfone (MSO(2)). Rumen contents were col... |
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Metabolism of sulfur-containing amino acids in the dermatophyte Microsporum gypseum. I. Neutral amino acids.
J. Basic Microbiol. 25(1) , 29-37, (1985) The dermatophyte Microsporum gypseum was cultivated on a glucose-arginine medium to which on out of six sulfur-containing amino acids was added (L-cystine, L-djenkolic acid, DL-lanthionine DL-homocystine, L-methionine, or L-methionine-sulfone at a concentrati... |
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Effects of singlet oxygen on the biological activity of DNA and its involvement in single strand-break formation.
Basic Life Sci. 49 , 473-7, (1988)
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Cross-talk and ammonia channeling between active centers in the unexpected domain arrangement of glutamate synthase.
Structure 8(12) , 1299-308, (2000) The complex iron-sulfur flavoprotein glutamate synthase catalyses the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine, a reaction in the plant and bacterial pathway for ammonia assimilation. The enzyme functions through three distinct a... |
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Antiinflammatory activity of methionine, methionine sulfoxide and methionine sulfone.
Agents Actions 31(1-2) , 110-2, (1990) The oxidation of methionine in peptides is often associated with the loss of biological activity. Since methionine showed good antiinflammatory activity, its oxidized products methionine sulfoxide and methionine sulfone were tested. The sulfone was more activ... |
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Insights into function, catalytic mechanism, and fold evolution of selenoprotein methionine sulfoxide reductase B1 through structural analysis.
J. Biol. Chem. 285(43) , 33315-23, (2010) Methionine sulfoxide reductases protect cells by repairing oxidatively damaged methionine residues in proteins. Here, we report the first three-dimensional structure of the mammalian selenoprotein methionine sulfoxide reductase B1 (MsrB1), determined by high ... |