辛伐他汀，斯伐他汀结构式
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常用名 | 辛伐他汀，斯伐他汀 | 英文名 | Simvastatin |
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| CAS号 | 79902-63-9 | 分子量 | 418.566 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 564.9±50.0 °C at 760 mmHg | |
| 分子式 | C25H38O5 | 熔点 | 139 °C | |
| MSDS | 中文版 美版 | 闪点 | 184.8±23.6 °C |
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Environmental friendly method for urban wastewater monitoring of micropollutants defined in the Directive 2013/39/EU and Decision 2015/495/EU.
J. Chromatogr. A. 1418 , 140-9, (2015) The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directiv... |
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Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.
Gynecol. Oncol. 135(2) , 333-41, (2014) Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin-OXysterol).Ovarian cancer cell lines were treated with combinations of statins and oxysterols. Cell viability was determined by a modified MTT ass... |
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Autocrine secretion of 15d-PGJ2 mediates simvastatin-induced apoptotic burst in human metastatic melanoma cells.
Br. J. Pharmacol. 171(24) , 5708-27, (2014) Despite new therapeutic approaches, metastatic melanomas still have a poor prognosis. Statins reduce low-density lipoprotein cholesterol and exert anti-inflammatory and anti-proliferative actions. We have recently shown that simvastatin triggers an apoptotic ... |
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Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298.
Biochim. Biophys. Acta 1850 , 1415-25, (2015) Statins are potent inhibitors of cholesterol biosynthesis and are clinically beneficial in preventing cardiovascular diseases, however, the therapeutic utility of these drugs is limited by myotoxicity. Here, we explored the mechanism of statin-mediated activa... |
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Statin treatment affects cytokine release and phagocytic activity in primary cultured microglia through two separable mechanisms.
Mol. Brain 7 , 85, (2015) As the primary immune cells of the central nervous system, microglia contribute to development, homeostasis, and plasticity of the central nervous system, in addition to their well characterized roles in the foreign body and inflammatory responses. Increasing... |
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Rapid analysis of pharmaceuticals and personal care products in fish plasma micro-aliquots using liquid chromatography tandem mass spectrometry.
J. Chromatogr. A. 1383 , 104-11, (2015) A sensitive analytical method based on liquid-liquid extraction (LLE) and liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed for rapid analysis of 11 pharmaceuticals and personal care products (PPCPs) in fish plasma micro-aliquots (∼20μL)... |
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Evaluation of bone repair of critical size defects treated with simvastatin-loaded poly(lactic-co-glycolic acid) microspheres in rat calvaria.
J. Biomater. Appl. 29(7) , 965-76, (2015) Statins are hypolipemiant drugs with osteoinductive effect. We evaluated the potential of simvastatin loaded into poly(lactic-co-glycolic acid) (PLGA) microspheres to heal critical size defects in rat calvaria.PLGA scaffolds (50:50 ratio) were synthesized as ... |
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Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram.
J. Pharm. Sci. 103(8) , 2509-19, (2014) To document the efficacy of clonazepam (CLZ) either free as a solution or loaded in solid lipid nanoparticles (CLZ-SLN) or mixed micelles (CLZ-MM), the in vitro blood-brain barrier permeability of the formulations was determined. Behavior and/or electroenceph... |
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Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD: the UMPIRE randomized clinical trial.
JAMA 310(9) , 918-29, (2013) Most patients with cardiovascular disease (CVD) do not take recommended medications long-term. The use of fixed-dose combinations (FDCs) improves adherence in several clinical areas. Previous trials of cardiovascular FDCs have assessed short-term effects comp... |
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Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals.
J. Chromatogr. A. 1345 , 139-53, (2014) An analytical method that facilitated the analysis of 11 pharmaceuticals residue (caffeine, prazosin, enalapril, carbamazepine, nifedipine, levonorgestrel, simvastatin, hydrochlorothiazide, gliclazide, diclofenac-Na, and mefenamic acid) with a single pre-trea... |