替米沙坦结构式
|
常用名 | 替米沙坦 | 英文名 | Telmisartan |
|---|---|---|---|---|
| CAS号 | 144701-48-4 | 分子量 | 514.617 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 771.9±70.0 °C at 760 mmHg | |
| 分子式 | C33H30N4O2 | 熔点 | 261-263°C | |
| MSDS | 中文版 美版 | 闪点 | 420.6±35.7 °C |
|
Preventing leptin resistance by blocking angiotensin II AT1 receptors in diet-induced obese rats.
Br. J. Pharmacol. 172(3) , 857-68, (2015) AT1 receptor blockers (ARBs) represent an approach for treating metabolic syndrome due to their potency in reducing hypertension, body weight and onset of type 2 diabetes. The mechanism underlying ARB-induced weight loss is still unclear.Leptin resistance tes... |
|
|
Behavior of sartans (antihypertensive drugs) in wastewater treatment plants, their occurrence and risk for the aquatic environment.
Environ. Sci. Pollut. Res. Int. 21(18) , 10830-9, (2014) Pharmaceuticals and other anthropogenic trace contaminants reach wastewaters and are often not satisfactorily eliminated in sewage treatment plants. These contaminants and/or their degradation products may reach surface waters, thus influencing aquatic life. ... |
|
|
Preconcentration of indapamide from human urine using molecularly imprinted solid-phase extraction.
J. Sep. Sci. 38 , 3090-5, (2015) A simple, sensitive, and selective molecularly imprinted solid-phase extraction and spectrophotometric method has been developed for the clean-up and preconcentration of indapamide from human urine. Molecularly imprinted polymers were prepared by a non-covale... |
|
|
Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms.
J. Pathol. 229(5) , 672-84, (2013) Mesangioproliferative glomerulonephritis is the most common nephritis worldwide. We examined the effects of low- and high-dose telmisartan, an angiotensin II receptor blocker, in rats with progressive anti-Thy1.1 mesangioproliferative glomerulonephritis in a ... |
|
|
A comparative pharmacokinetic study of a fixed dose combination for essential hypertensive patients: a randomized crossover study in healthy human volunteers.
Drug Res. (Stuttg.) 63(4) , 177-84, (2013) This study was aimed to investigate the relative bioavailability of fixed-dose-combination (FDC) product of amlodipine, telmisartan and hydrochlorothiazide with individual marketed products in healthy male volunteers. Control of blood pressure with fixed dose... |
|
|
Telmisartan or valsartan alone or in combination with hydrochlorothiazide: a review.
Clin. Exp. Hypertens. 35(1) , 50-60, (2013) The aim of this review was to compare telmisartan and valsartan in the treatment of hypertension. PubMed searches were conducted to identify randomized trials (n = 14) comparing the two agents, alone or combined with hydrochlorothiazide. With one exception, a... |
|
|
Acute and subchronic exposure to air particulate matter induces expression of angiotensin and bradykinin-related genes in the lungs and heart: Angiotensin-II type-I receptor as a molecular target of particulate matter exposure.
Part. Fibre Toxicol. 12 , 17, (2015) Particulate matter (PM) adverse effects on health include lung and heart damage. The renin-angiotensin-aldosterone (RAAS) and kallikrein-kinin (KKS) endocrine systems are involved in the pathophysiology of cardiovascular diseases and have been found to impact... |
|
|
Novel strategy for biofilm inhibition by using small molecules targeting molecular chaperone DnaK.
Antimicrob. Agents Chemother. 59(1) , 633-41, (2014) Biofilms are complex communities of microorganisms that attach to surfaces and are embedded in a self-produced extracellular matrix. Since these cells acquire increased tolerance against antimicrobial agents and host immune systems, biofilm-associated infecti... |
|
|
Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8.
Biol. Pharm. Bull. 38 , 1975-9, (2015) Arachidonic acid (AA) is metabolized to epoxyeicosatrienoic acids (EETs) via cytochrome enzymes such as CYP 2C9, 2C8 and 2J2. EETs play a role in cardioprotection and regulation of blood pressure. Recently, adverse reactions such as sudden heart attack and fa... |
|
|
Bio-generation of stable isotope-labeled internal standards for absolute and relative quantitation of phase II drug metabolites in plasma samples using LC-MS/MS.
Anal. Bioanal. Chem 407 , 4053-63, (2015) Quantification of drug metabolites in biological samples has been of great interest in current pharmaceutical research, since metabolite concentrations and pharmacokinetics can contribute to a better understanding of the toxicity of drug candidates. Two major... |