聚(D,L-乳酸-co-乙醇酸)

Eur. J. Pharm. Biopharm. 92 , 1-7, (2015)

This study describes how protein release from polymer matrices correlate with simple measurements on the intrinsic viscosity of the polymer solutions used for casting the matrices and calculations of the solubility parameters of polymers and solvents used.Mat...

Parasit. Vectors 6 , 34, (2013)

Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have ...

J. Am. Coll. Surg. 218(1) , 102-7, (2014)

Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorba...

Int. J. Pharm. 454(1) , 344-53, (2013)

Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were i...

Nanotechnology 23(50) , 505101, (2012)

Our purpose was to assess sustained delivery and enhanced efficacy of pirfenidone-loaded nanoparticles after intratracheal instillation.Poly(lactide-co-glycolide) nanoparticles containing pirfenidone (NPs) were prepared and characterized. Biodistribution of N...

Anticancer Res. 33(6) , 2425-34, (2013)

Extreme hydrophobicity and poor stability of SN-38, a highly potent topoisomerase I inhibitor, has prevented its clinical use. Its encapsulation into nanoparticles may be a way to overcome these problems. Here we report the use of SN-38-loaded hyaluronic acid...

Food Chem. Toxicol. 52 , 143-52, (2013)

Continuous dopaminergic stimulation (CDS) is an important drug development strategy in the treatment of Parkinson's disease (PD). Rotigotine is a non-ergoline D(3)/D(2)/D(1) dopamine receptor agonist for treating PD. As a new treatment option for CDS, rotigot...

Ophthalmology 120(6) , 1300-4, (2013)

To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies.Retrospective, interventional cohort study.All children undergoing primary enucleation without adjuvant therapies between 1999 ...

Int. J. Surg. 11(1) , 81-4, (2013)

Chronic pain may be a major long-term problem related to mesh material and operative trauma in inguinal hernioplasty.Lichtenstein hernioplasty was performed under local anaesthesia in 312 patients by the same surgeon and technique between 2003 and 2005. The p...

Ophthal. Plast. Reconstr. Surg. 29(5) , 400-2, (2013)

To describe a simple technique to correct tarsal lower eyelid ectropion with or without marked eyelid laxity (The Leicester Modified Suture technique).A retrospective interventional case series of patients undergoing correction of tarsal ectropion with invert...