(|S|)-(+)-α-苯甘氨酸

Bioorg. Med. Chem. Lett. 16 , 1138-41, (2006)

During the last 10-15 years, an increase of Clostridium botulinum associated diseases in cattle has been observed in Germany. The reason for this development is currently unknown. The normal intestinal microflora is a critical factor in preventing intestinal ...

Enzyme Microb. Technol. 51(2) , 107-12, (2012)

α-Amino acid ester hydrolases (AEHs) are enzymes of interest to the semi-synthesis of β-lactam antibiotics with α-amino, such as cephalexin and cefaclor. An undesired side reaction, the hydrolysis of α-amino acid ester, had hindered applications in antibiotic...

J. Pharmacol. Exp. Ther. 330(3) , 783-91, (2009)

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel. The mutations G551D and G1349D, which affect the nucleotide-binding domains (NBDs) of CFTR protein, reduce channel activity. This defe...

Bioorg. Med. Chem. Lett. 20(1) , 87-91, (2010)

A developing therapy of cystic fibrosis caused by the DeltaF508 mutation in CFTR employs correction of defective CFTR chloride channel gating by a 'potentiator' and of defective CFTR protein folding by a 'corrector'. Based on SAR data for phenylglycine-type p...

Bioorg. Med. Chem. Lett. 15(23) , 5344-52, (2005)

We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.

Biochim. Biophys. Acta 1770(11) , 1585-92, (2007)

Following induction with D-phenylglycine both d-phenylglycine aminotransferase activity and benzoylformate decarboxylase activity were observed in cultures of Pseudomonas stutzeri ST-201. Induction with benzoylformate, on the other hand, induced only benzoylf...

Org. Biomol. Chem. 2(23) , 3470-5, (2004)

To clarify the structural scaffold of (+)-18-crown-6 tetracarboxylic acid ((+)-18C6H4) for the optical resolution of a chiral amino acid, the crystal structures of its equimolar complexes with L- and D-isomers of tyrosine (Tyr), isoleucine (Ile), methionine (...

J. Chem. Phys. 128(18) , 184313, (2008)

We investigated the conformational structures of L-phenylglycine in the gas phase by photoionization and double resonance spectroscopy techniques as well as high-level ab initio calculations. The UV-UV and IR-UV double resonance spectroscopy suggested that th...

J. Org. Chem. 75(3) , 660-5, (2010)

In terms of chiral recognition for racemic aryl methyl sulfoxides in the solid state, three kinds of crystalline (S)-alkylglycyl-(S)-phenylglycines were examined as potential dipeptides host molecules. When (S)-alanyl-(S)-phenylglycines [(S,S)-Ala-Phg] crysta...

Biochemistry 52(1) , 228-38, (2013)

The substrate specificities of two incorrectly annotated enzymes belonging to cog3964 from the amidohydrolase superfamily were determined. This group of enzymes are currently misannotated as either dihydroorotases or adenine deaminases. Atu3266 from Agrobacte...