2,3-萘酞菁双(三己基硅氧基)硅烷
2,3-萘酞菁双(三己基硅氧基)硅烷结构式
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常用名 | 2,3-萘酞菁双(三己基硅氧基)硅烷 | 英文名 | bis(trihexylsiloxy)silicon 2,3-naph- thalocyanine |
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| CAS号 | 92396-88-8 | 分子量 | 1327.92000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C84H90N8O2Si3 | 熔点 | 270ºC (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Phthalocyanine photodynamic therapy: disparate effects of pharmacologic inhibitors on cutaneous photosensitivity and on tumor regression.
Photochem. Photobiol. 65(5) , 895-901, (1997) The phthalocyanines are promising second-generation photosensitizers that are being evaluated for the photodynamic therapy (PDT) of malignant tumors. In vivo studies with the silicon phthalocyanine Pc 4 have shown that it is highly effective at causing regres... |
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Plasma pharmacokinetics and tissue distribution in CD2F1 mice of Pc4 (NSC 676418), a silicone phthalocyanine photodynamic sensitizing agent.
Cancer Chemother. Pharmacol. 44(4) , 283-94, (1999) Pc4 is a silicone phthalocyanine photosensitizing agent that is entering clinical trials. Studies were undertaken in mice to develop a suitable formulation and analytical methodology for use in pharmacokinetic studies and to define the plasma pharmacokinetics... |
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Silicon phthalocyanine Pc 4 and red light causes apoptosis in HIV-infected cells.
Photochem. Photobiol. 65(3) , 456-60, (1997) The silicon phthalocyanine HOSiPcOSi(CH3)2(CH2)3 N(CH3)2 (Pc 4), is being studied as a photosensitizer for virus inactivation in red blood cell concentrates (RBCC). The RBCC spiked with cell-free human immunodeficiency virus (HIV) or with HIV actively replica... |
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Photodynamic activities of silicon phthalocyanines against achromic M6 melanoma cells and healthy human melanocytes and keratinocytes.
J. Photochem. Photobiol. B, Biol. 48(1) , 48-56, (1999) Dichlorosilicon phthalocyanine (Cl2SiPc) and bis(tri-n-hexylsiloxy) silicon phthalocyanine (HexSiPc) have been evaluated in vitro as potential photosensitizers for photodynamic therapy (PDT) against the human amelanotic melanoma cell line M6. Each photosensit... |
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Structure-activity and mechanism studies on silicon phthalocyanines with Plasmodium falciparum in the dark and under red light.
Photochem. Photobiol. 66(2) , 282-7, (1997) Syntheses for the new photosensitizers HOSiPcOSi(CH3)2(CH2)3N(CH1)1 or 3(CH3)2, Pc 34 and Pc 25, have been developed and the order of activity of these photosensitizers and the previously reported photosensitizer Pc 4, HOSiPcOSi(CH3)2(CH2)3N(CH3)2, in the dar... |
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Fumonisin B1 does not prevent apoptosis in A431 human epidermoid carcinoma cells after photosensitization with a silicon phthalocyanine.
J. Photochem. Photobiol. B, Biol. 57(2-3) , 132-41, (2000) Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 (Pc 4-PDT), an apoptosis inducer, is associated with accumulation of ceramide in various cell lines. The role of ceramide in Pc 4-PDT-induced apoptosis was investigated in A431 cells. Caspase-3... |
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Variation in photodynamic efficacy during the cellular uptake of two phthalocyanine photosensitizers.
Photochem. Photobiol. 67(6) , 720-8, (1998) A decrease in the efficacy of photodynamic therapy (PDT) with phthalocyanine photosensitizers was observed for lymphoblastic murine and human cell lines as the time between the addition of the photosensitizer, aluminum phthalocyanine (AIPc), to the culture me... |
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Immunosuppressive effects of silicon phthalocyanine photodynamic therapy.
Photochem. Photobiol. 70(1) , 72-7, (1999) The purpose of this study was to determine if silicon phthalocyanine 4 (Pc 4), a second-generation photosensitizer being evaluated for the photodynamic therapy (PDT) of solid tumors, was immunosuppressive. Mice treated with Pc 4 PDT 3 days before dinitrofluor... |
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Photosensitized decontamination of blood with the silicon phthalocyanine Pc 4: no activation of the human immunodeficiency virus promoter.
Photochem. Photobiol. 65(3) , 461-4, (1997) Photochemical decontamination of red blood cell concentrates (RBCC) with the silicon phthalocyanine Pc 4 and red light is being studied to enhance the viral safety of blood transfusion. Recent reports indicate that treatments with radiation and various photot... |
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Recombinant human tumor necrosis factor alpha does not potentiate cell killing after photodynamic therapy with a silicon phthalocyanine in A431 human epidermoid carcinoma cells.
Int. J. Oncol. 18(2) , 411-5, (2001) Photodynamic therapy (PDT) is a novel cancer treatment utilizing a photosensitizer, visible light and oxygen. PDT with the silicon phthalocyanine Pc 4, a new photosensitizer, is highly effective in cancer cell destruction and tumor ablation. The mechanisms un... |