去甲氟西汀
去甲氟西汀结构式
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常用名 | 去甲氟西汀 | 英文名 | Norfluoxetine hydrochloride |
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| CAS号 | 57226-68-3 | 分子量 | 331.760 | |
| 密度 | 1.204g/cm3 | 沸点 | 381.1ºC at 760 mmHg | |
| 分子式 | C16H17ClF3NO | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 184.3ºC |
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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science 347(6227) , 1256-9, (2015) TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the mechanisms that control channel gating are unclear. Here we present crystal structures of th... |
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The pH-dependent toxicity of basic pharmaceuticals in the green algae Scenedesmus vacuolatus can be explained with a toxicokinetic ion-trapping model.
Aquat. Toxicol. 101(1) , 266-75, (2011) Several previous studies revealed that pharmaceuticals with aliphatic amine function exhibit a higher toxicity toward algae than toward other aquatic organisms. Here we investigated the pH-dependent toxicity of the five basic pharmaceuticals fluoxetine, its m... |
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Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem.
Drug Metab. Dispos. 38(6) , 963-72, (2010) Three secondary amines desipramine (DES), (S)-fluoxetine [(S)-FLX], and N-desmethyldiltiazem (MA) undergo N-hydroxylation to the corresponding secondary hydroxylamines [N-hydroxydesipramine, (S)-N-hydroxyfluoxetine, and N-hydroxy-N-desmethyldiltiazem] by cyto... |
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Three-phase, liquid-phase microextraction combined with high performance liquid chromatography-fluorescence detection for the simultaneous determination of fluoxetine and norfluoxetine in human plasma.
J. Pharm. Biomed. Anal. 51(1) , 170-7, (2010) A three-phase, liquid-phase microextraction using a hollow fibre (HF-LPME) combined with high performance liquid chromatography-fluorescence detection (HPLC-FL) was developed for the analysis of fluoxetine (FLX) and its active metabolite, norfluoxetine (NFLX)... |
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Pharmacokinetics and pharmacodynamics of norfluoxetine in rats: Increasing extracellular serotonin level in the frontal cortex.
Pharmacol. Biochem. Behav. 92(3) , 469-73, (2009) Norfluoxetine is the most important active metabolite of the widely used antidepressant fluoxetine. Although the pharmacokinetics/pharmacodynamics (PK/PD) relationship and neurochemical profile of fluoxetine is well characterized in human and in animals, litt... |
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The effects of antidepressants on mitochondrial function in a model cell system and isolated mitochondria.
Neurochem. Res. 36(2) , 327-38, (2011) The in vitro effects of antidepressant drugs on mitochondrial function were investigated in a CHOβ(2)SPAP cell line used previously to determine the effects of antidepressants on gene transcription (Abdel-Razaq et al., Biochem Pharmacol 73:1995-2003, 2007) an... |
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Effect of chronic fluoxetine treatment on male and female rat erythrocyte and prefrontal cortex fatty acid composition.
Prog. Neuropsychopharmacol. Biol. Psychiatry 34(7) , 1317-21, (2010) Omega-3 (n-3) polyunsaturated fatty acids (PUFA) and fluoxetine (FLX) have additive effects in the treatment of major depressive disorder, and FLX up-regulates genes that regulate fatty acid biosynthesis in vitro. Although these data suggest that FLX may augm... |
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Disposition of chiral and racemic fluoxetine and norfluoxetine across childbearing.
J. Clin. Psychopharmacol. 30(4) , 381-6, (2010) To add to the limited data on the clinical pharmacology of antidepressants during pregnancy, we examined the dose-corrected chiral and racemic levels (level/dose) of fluoxetine (FLX) and norfluoxetine (NorFLX) during pregnancy and early postpartum.The authors... |
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Simultaneous determination of fluoxetine and norfluoxetine enantiomers using isotope discrimination mass spectroscopy solution method and its application in the CYP2C9-mediated stereoselective interactions.
J. Chromatogr. A. 1236 , 97-104, (2012) In this study, we developed an LC-MS/MS method based on an isotope discrimination mass spectroscopy solution (IDMSS) technology to simultaneously quantify enantiomers of fluoxetine (FLX) and norfluoxetine (NFLX) in a CYP2C9 incubation mixture. S-FLX and S-NFL... |
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Therapeutic drug monitoring of children and adolescents treated with fluoxetine.
Pharmacopsychiatry 45(2) , 72-6, (2012) Information about therapeutic serum levels of fluoxetine (FLX) and its major metabolite norfluoxetine (NORFLX) in children and adolescents is scarce.Therapeutic drug monitoring (TDM) of FLX was routinely performed in 71 subjects treated for a major depressive... |