2′,3′-二脱氧腺苷5′-三磷酸钠盐

Nucleic Acids Res. 42(10) , 6337-51, (2014)

Poly(ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear enzyme in mammalian cells. The enzyme synthesizes polymers of ADP-ribose from the coenzyme NAD(+) and plays multifaceted roles in cellular responses to genotoxic stress, including DNA repair. It ha...

Nucleic Acids Res. 41 , 3257-73, (2013)

In spite of the many developments in synthetic oligonucleotide (ON) chemistry and design, invasion into double-stranded DNA (DSI) under physiological salt and pH conditions remains a challenge. In this work, we provide a new ON tool based on locked nucleic ac...

PLoS ONE 4 , e7453, (2009)

Many techniques for the study of complex populations provide either specific information on a small number of variants or general information on the entire population. Here we describe a powerful new technique for elucidating mutation frequencies at each geno...

Mol. Vis. 15 , 980-4, (2009)

To describe the first cataract-causing recessive mutation in the crystalline, alpha-b gene CRYAB.Homozygosity mapping complemented by linkage analysis was performed in a family with autosomal recessive juvenile cataract.A homozygous missense mutation in CRYAB...

RNA 22 , 204-15, (2016)

Telomerase is a ribonucleoprotein (RNP) enzyme that requires an integral telomerase RNA (TR) subunit, in addition to the catalytic telomerase reverse transcriptase (TERT), for enzymatic function. The secondary structures of TRs from the three major groups of ...

Mol. Vis. 18 , 1197-214, (2012)

Retinitis pigmentosa (RP) is a progressive retinal degeneration in which the retina loses nearly all of its photoreceptor cells and undergoes major structural changes. Little is known regarding the role the resident glia, the Müller glia, play in the progress...

J. Comp. Neurol. 509 , 225-38, (2008)

Müller glial cells are the major type of glia in the mammalian retina. To identify the molecular machinery that defines Müller glial cell identity and function, single cell gene expression profiling was performed on Affymetrix microarrays. Identification of a...

PLoS Genet. 9 , e1003479, (2013)

Nucleosomes in all eukaryotes examined to date adopt a characteristic architecture within genes and play fundamental roles in regulating transcription, yet the identity and precise roles of many of the trans-acting factors responsible for the establishment an...

Nucleic Acids Res. 40 , 9089-101, (2012)

The choice for a polyadenylation site determines the length of the 3'-untranslated region (3'-UTRs) of an mRNA. Inclusion or exclusion of regulatory sequences in the 3'-UTR may ultimately affect gene expression levels. Poly(A) binding protein nuclear 1 (PABPN...

BMC Genomics 13 , 177, (2012)

Second-generation sequencing technologies have revolutionized our ability to recover genetic information from the past, allowing the characterization of the first complete genomes from past individuals and extinct species. Recently, third generation Helicos s...