丁位己内酯
丁位己内酯结构式
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常用名 | 丁位己内酯 | 英文名 | d-Hexanolactone |
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| CAS号 | 823-22-3 | 分子量 | 114.142 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 215.7±8.0 °C at 760 mmHg | |
| 分子式 | C6H10O2 | 熔点 | 18ºC | |
| MSDS | 中文版 美版 | 闪点 | 79.8±15.9 °C |
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Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity
Bioorg. Med. Chem. 16 , 7504-9, (2008) Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate remain elusive. PON1 hydrolyzes organophosphates, arylesters an... |
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Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities.
J. Lipid Res. 46(6) , 1239-47, (2005) The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and PON3. Their physiological role(s) and natural substrates are uncertain. We developed a baculovirus-mediated expression system, suitable for all three human PONs, and optimized proc... |
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Lactonase and lactonizing activities of human serum paraoxonase (PON1) and rabbit serum PON3.
Biochem. Pharmacol. 66(6) , 887-96, (2003) Human paraoxonase (PON1) was previously shown to hydrolyze over 30 different lactones (cyclic esters). In the present study purified human PON1 was found to catalyze the reverse reaction (lactonization) of a broad range of hydroxy acids. Hydroxy acid lactoniz... |