甲磺酸多沙唑嗪
甲磺酸多沙唑嗪结构式
|
常用名 | 甲磺酸多沙唑嗪 | 英文名 | Doxazosin mesylate |
|---|---|---|---|---|
| CAS号 | 77883-43-3 | 分子量 | 547.581 | |
| 密度 | N/A | 沸点 | 718ºC at 760 mmHg | |
| 分子式 | C24H29N5O8S | 熔点 | 275-277ºC | |
| MSDS | 中文版 美版 | 闪点 | 388ºC |
|
Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.
J. Clin. Invest. 123(12) , 5119-34, (2013) A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human diseases and lead to therapy development. Here, we applied this strategy to identify pharmacological targe... |
|
|
The efficacy and safety of alpha-1 blockers for benign prostatic hyperplasia: an overview of 15 systematic reviews.
Curr. Med. Res. Opin. 29(3) , 279-87, (2013) A great number of clinical trials and systematic reviews have evaluated the efficacy and safety of α(1) blockers for benign prostatic hyperplasia (BPH). We carried out an overview of reviews to provide an up-to-date summary of evidence regarding the efficacy ... |
|
|
[Results of open multicenter study of the safety of doxazosin in combination with indigal in men with stages I-II prostatic adenoma].
Urologiia. (2) , 42-4, 46, (2013) The article presents a method of conservative treatment of men with I-II stage prostatic adenoma using a combination of doxazosin and indigal, which has antioxidant, antiproliferative and anti-inflammatory properties, that allowed improving urodynamic paramet... |
|
|
Irbesartan, an FDA approved drug for hypertension and diabetic nephropathy, is a potent inhibitor for hepatitis B virus entry by disturbing Na(+)-dependent taurocholate cotransporting polypeptide activity.
Antiviral Res. 120 , 140-6, (2015) The liver-specific Na(+)-dependent taurocholate cotransporting polypeptide (NTCP) was recently identified as an entry receptor for hepatitis B virus (HBV) hepatotropic infection. In this study, an NTCP-overexpressing HepG2 cell line named HepG2.N9 susceptible... |
|
|
Long-term effects of doxazosin, finasteride and combination therapy on quality of life in men with benign prostatic hyperplasia.
J. Urol. 190(1) , 187-93, (2013) We examined the effects of doxazosin, finasteride and combination therapy among men with benign prostatic hyperplasia on quality of life assessed with MOS-SF-36 (Medical Outcomes Study Short-Form 36) and 2 disease specific instruments (BII, benign prostatic h... |
|
|
Regulation of apoptosis in HL-1 cardiomyocytes by phosphorylation of the receptor tyrosine kinase EphA2 and protection by lithocholic acid.
Br. J. Pharmacol. 167(7) , 1563-72, (2012) Heart failure and atrial fibrillation are associated with apoptosis of cardiomyocytes, suggesting common abnormalities in pro-apoptotic cardiac molecules. Activation of the receptor tyrosine kinase EphA2 causes apoptosis in vitro, and dysregulation of EphA2-d... |
|
|
Lower urinary tract symptoms revisited.
Int. J. Clin. Pract. 66(6) , 527-9, (2012)
|
|
|
Fibrosis-related gene expression in the prostate is modulated by doxazosin treatment.
Life Sci. 91(25-26) , 1281-7, (2012) To gain new insights into the molecular mechanisms of action of doxazosin, we investigated the prostatic stroma ultrastructure and the expression of genes involved with fibrosis, such as collagen type I and III (COL1A1 and COL3A1, respectively) and TGF-beta 1... |
|
|
Hemodynamic effects of once-daily tadalafil in men with signs and symptoms of benign prostatic hyperplasia on concomitant α1-adrenergic antagonist therapy: results of a multicenter randomized, double-blind, placebo-controlled trial.
Urology 79(4) , 875-82, (2012) To investigate the safety of daily coadministration of α-blockers with tadalafil 5 mg in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia. The standard-of-care medical therapy for moderate to severe symptoms of benign prostatic ... |
|
|
Disrupted regulation of ghrelin production under antihypertensive treatment in spontaneously hypertensive rats.
Circ. J. 76(6) , 1423-9, (2012) Ghrelin is an acylated peptide hormone mainly secreted from the stomach. When administrated externally it modulates vascular tone mainly through the regulation of autonomic nerve activity. However, the effects of blood pressure (BP) on the production and secr... |