3,4,5-三甲氧基苯甲酸(8-二乙氨基正辛基)酯盐酸盐
3,4,5-三甲氧基苯甲酸(8-二乙氨基正辛基)酯盐酸盐结构式
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常用名 | 3,4,5-三甲氧基苯甲酸(8-二乙氨基正辛基)酯盐酸盐 | 英文名 | TMB-8 |
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| CAS号 | 53464-72-5 | 分子量 | 431.99 | |
| 密度 | 1.018g/cm3 | 沸点 | 461.2ºC at 760mmHg | |
| 分子式 | C22H38ClNO5 | 熔点 | 94-97 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 232.8ºC |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Effect of anabasine on catecholamine secretion from the perfused rat adrenal medulla.
J. Cardiol. 50(6) , 351-62, (2007) The present study was designed to investigate the characteristic effects of anabasine on secretion of catecholamines (CA) from the isolated perfused rat adrenal gland and to establish its mechanism of adrenomedullary secretion. |
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Two phases of calcium requirement during starfish meiotic maturation.
Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 147(2) , 432-7, (2007) During meiosis in oocytes of the starfish, Asterina pectinifera, a Ca(2+) transient has been observed. To clarify the role of Ca(2+) during oocyte maturation in starfish, an intracellular Ca(2+) blocker, TMB-8, was applied. The oocyte maturation induced by 1-... |
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Molecular mechanisms of short-term habituation in the leech Hirudo medicinalis.
Behav. Brain Res. 229(1) , 235-43, (2012) Although habituation is ubiquitous in the animal kingdom, its underlying mechanisms remain poorly understood. In this study, we began to explore the molecular cascades underlying short-term habituation in the leech Hirudo medicinalis. In H. medicinalis, a tra... |
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Effects of motilin on intracellular free calcium in cultured smooth muscle cells from the antrum of neonatal rats.
Acta Physiol. (Oxf.) 199(1) , 53-61, (2010) The aim of this study was to determine the effects of motilin on [Ca(2+)](i) regulation and its underlying molecular mechanism in cultured antral smooth muscle cells (ASMCs).Antral cells were isolated and cultured from neonatal rats, and then the [Ca(2+)](i) ... |
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Nitric oxide-induced endoplasmic reticulum stress activates the expression of cargo receptor proteins and alters the glycoprotein transport to the Golgi complex.
Int. J. Biochem. Cell Biol. 38(12) , 2040-8, (2006) The endoplasmic reticulum Golgi intermediate compartment 53 protein recycles continuously between the endoplasmic reticulum and the Golgi complex and ensures the anterograde transport of specific glycoproteins with the assistance of the Multiple Clotting Fact... |
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Nimodipine inhibits TMB-8 potentiation of AMPA-induced hippocampal neurodegeneration.
J. Neurosci. Res. 87(5) , 1240-9, (2009) Human cerebral calcification has been related to deregulation of intracellular calcium homeostasis. In rat basal ganglia, nimodipine and TMB-8, two commonly used calcium antagonists, worsen the chronic AMPA-induced lesion, whereas only nimodipine potentiates ... |
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Involvement of protein kinase C and IP3-mediated Ca2+ release in activity modulation by paraoxon in snail neurons.
Eur. J. Pharmacol. 571(2-3) , 81-7, (2007) We have previously reported that paraoxon, an organophosphate compound, at submicromolar concentrations effectively suppresses Ca2+ action potentials and modulates the activity of snail neurons. This effect was unrelated to acetylcholinesterase inhibition but... |
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Effect of theophylline and aminophylline on transmitter release at the mammalian neuromuscular junction is not mediated by cAMP.
Clin. Exp. Pharmacol. Physiol. 33(5-6) , 465-70, (2006) 1. Theophylline and aminophylline have been widely used as inhibitors of phosphodiesterase when examining the role of cAMP in regulating cell function. In reality, however, these phosphodiesterase inhibitors may have additional sites of action that could comp... |
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Alzheimer's disease related peptides affected cholinergic receptor mediated poly(ADP-ribose) polymerase activity in the hippocampus.
Folia Neuropathol. 43(3) , 139-42, (2005) Our previous studies indicated that Alzheimer's disease (AD) related amyloid beta peptide (Abeta) significantly altered muscarinic cholinergic receptor (mChR) signaling on the level of G protein regulated phospholipase C (PLC) leading to the lower formation o... |