FPL 64176
FPL 64176结构式
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常用名 | FPL 64176 | 英文名 | FPL64176 |
|---|---|---|---|---|
| CAS号 | 120934-96-5 | 分子量 | 347.40700 | |
| 密度 | 1.174g/cm3 | 沸点 | 547.8ºC at 760mmHg | |
| 分子式 | C22H21NO3 | 熔点 | 144 - 145 °C | |
| MSDS | 中文版 美版 | 闪点 | 285.1ºC |
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Metformin as adjunct antituberculosis therapy.
Sci. Transl. Med. 6(263) , 263ra159, (2014) The global burden of tuberculosis (TB) morbidity and mortality remains immense. A potential new approach to TB therapy is to augment protective host immune responses. We report that the antidiabetic drug metformin (MET) reduces the intracellular growth of Myc... |
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A pharmacological model for calcium overload-induced tachycardia in isolated rat left atria.
Eur. J. Pharmacol. 576(1-3) , 122-31, (2007) Few experimental models produce spontaneous tachycardia in normal left atria to allow the study of the cellular mechanisms underlying this contributor to atrial fibrillation. We reported 2-aminoethoxydiphenyl borate (2-APB) that provokes sporadic spontaneous ... |
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Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels.
Brain Res. 1276 , 159-70, (2009) Estrogen-mediated neuroprotection is observed in neurodegenerative disease and neurotrauma models; however, determining a mechanism for these effects has been difficult. We propose that estrogen may limit cell death in the nervous system tissue by inhibiting ... |
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Acute atrial arrhythmogenesis in murine hearts following enhanced extracellular Ca(2+) entry depends on intracellular Ca(2+) stores.
Acta Physiol. (Oxf.) 198(2) , 143-58, (2010) To investigate the effect of increases in extracellular Ca(2+) entry produced by the L-type Ca(2+) channel agonist FPL-64176 (FPL) upon acute atrial arrhythmogenesis in intact Langendorff-perfused mouse hearts and its dependence upon diastolic Ca(2+) release ... |
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Perspective on the role of P2X-purinoceptor activation in human vas deferens contractility.
Exp. Physiol. 97(5) , 583-602, (2012) The contractile actions of α,β-methylene ATP (α,β-meATP) and ATP and the effects of K(+) channel blockers in longitudinal and circular muscles of human vas deferens were investigated with a view to clarifying the functional importance of P2X(1)-purinoceptor a... |
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An L-type calcium channel agonist, bay K8644, extends the window of intervention against ischemic neuronal injury.
Mol. Neurobiol. 47(1) , 280-9, (2013) Our previous data indicate that the inhibition of L-type calcium channels (LTCCs) might be the cause of post-ischemic neuronal injury and that the activation of LTCCs can give rise to neuroprotection. In the present study, we aimed to profile the intervention... |
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Voltage-gated calcium channels provide an alternate route for iron uptake in neuronal cell cultures.
Neurochem. Res. 32(10) , 1686-93, (2007) Recent studies suggest that iron enters cardiomyocytes via the L-type voltage-gated calcium channel (VGCC). The neuronal VGCC may also provide iron entry. As with calcium, extraneous iron is associated with the pathology and progression of neurodegenerative d... |
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L-type calcium channel agonist induces correlated depolarizations in mice lacking the beta2 subunit nAChRs.
Vision Res. 44(28) , 3347-55, (2004) Retinal waves are mediated in part by activation of nicotinic receptors containing the beta2 subunit. Mice deficient in beta2 containing nAChRs have maintained firing of action potentials but do not support correlated waves. As a result, beta2-/- mice have in... |
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Role of PKG-L-type calcium channels in the antinociceptive effect of intrathecal sildenafil.
J. Vet. Sci. 11(2) , 103-6, (2010) Sildenafil increases the cyclic guanosine monophosphate (cGMP) by inhibition of a phosphodiesterase 5, thereby leading to an antinociceptive effect. The increased cGMP may exert the effect on an L-type calcium channel through the activation of protein kinase ... |
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Intracellular acidification in neurons induced by ammonium depends on KCC2 function.
Eur. J. Neurosci. 23(2) , 454-64, (2006) The Cl(-)-extruding neuron-specific K(+)-Cl(-) cotransporter KCC2, which establishes hyperpolarizing inhibition, can transport NH(4) (+) instead of K(+). It is, however, not clear whether KCC2 provides the only pathway for neuronal NH(4) (+) uptake. We theref... |