QNZ (EVP4593)
QNZ (EVP4593)结构式
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常用名 | QNZ (EVP4593) | 英文名 | QNZ (EVP4593) |
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| CAS号 | 545380-34-5 | 分子量 | 356.420 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 602.0±55.0 °C at 760 mmHg | |
| 分子式 | C22H20N4O | 熔点 | 169-175ºC | |
| MSDS | 美版 | 闪点 | 317.9±31.5 °C |
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By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization.
Oncotarget 6 , 9140-59, (2015) Interstitial fluid flow and associated shear stress are relevant mechanical signals in cartilage and bone (patho)physiology. However, their effects on chondrosarcoma cell motility, invasion and metastasis have yet to be delineated. Using human SW1353, HS.819.... |
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Sirtuin 6 promotes transforming growth factor-β1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence.
Cancer Sci. 106 , 559-66, (2015) Sirtuin 6 (SIRT6) can function as a tumor suppressor by suppressing aerobic glycolysis and apoptosis resistance. However, the negative effect of SIRT6 on cellular senescence implies that it may also have the potential to promote tumor development. Here we rep... |
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Hepatitis C virus NS5A drives a PTEN-PI3K/Akt feedback loop to support cell survival.
Liver Int. 35 , 1682-91, (2015) Decreased levels of phosphatase and tensin homologue (PTEN) are associated with hepatocellular carcinoma (HCC) pathogenesis and poor prognosis in hepatitis C virus (HCV)-infected HCC patients. The molecular processes governing the reduction in PTEN and outcom... |
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Enhancement of adoptive T cell transfer with single low dose pretreatment of doxorubicin or paclitaxel in mice.
Oncotarget 6 , 44134-50, (2016) Ex vivo expansion of CD8+ T-cells has been a hindrance for the success of adoptive T cell transfer in clinic. Currently, preconditioning with chemotherapy is used to modulate the patient immunity before ACT, however, the tumor microenvironment beneficial for ... |
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Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential.
FASEB J. 29(2) , 662-70, (2015) The incidence of certain angiogenesis-dependent diseases is higher in Caucasians than in African Americans. Angiogenesis is amplified in wound healing and cornea models in albino C57 mice compared with black C57 mice. Moreover, mouse and human melanocytes wit... |
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Fenofibrate prevents the disruption of the outer blood retinal barrier through downregulation of NF-κB activity.
Acta Diabetol. 53 , 109-18, (2016) There is clinical evidence that fenofibrate, a PPARα agonist, arrests the progression of diabetic macular edema (DME). However, the underlying mechanisms of this beneficial effect remain to be elucidated. We previously reported that fenofibric acid (FA), the ... |
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The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.
J. Immunol. 195 , 695-705, (2015) Linker for activation of T cells (LAT) is a transmembrane adaptor protein that is highly tyrosine phosphorylated upon engagement of the TCR. Phosphorylated LAT binds Grb2, Gads, and phospholipase C (PLC)γ1 to mediate T cell activation, proliferation, and cyto... |