苯并[c]吖啶
![苯并[c]吖啶结构式](https://image.chemsrc.com/caspic/031/225-51-4.png)
苯并[c]吖啶结构式
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常用名 | 苯并[c]吖啶 | 英文名 | BENZ(C)ACRIDINE |
|---|---|---|---|---|
| CAS号 | 225-51-4 | 分子量 | 229.276 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 446.2±14.0 °C at 760 mmHg | |
| 分子式 | C17H11N | 熔点 | 132°C | |
| MSDS | N/A | 闪点 | 201.4±12.7 °C |
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Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons.
Bioorg. Med. Chem. 8(5) , 1171-82, (2000) Coralyne and several other synthetic benzo[a,g]quinolizium derivatives related to protoberberine alkaloids have exhibited activity as topoisomerase poisons. These compounds are characterized by the presence of a positively charged iminium group, which has bee... |
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Heteroatom effects in chemical carcinogenesis: effects of ring heteroatoms on ease of carbocation formation.
Cancer Biochem. Biophys. 7(1) , 53-60, (1983) The presence of a heteroatom can influence the ease with which a PAH diol-epoxide forms a triol carbocation. The influence of the heteroatom should be greatest when it is located where the PAH undergoes maximum charge change upon ionization. Extended Hückel, ... |
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Differentiated genotoxic response of carcinogenic and non-carcinogenic benzacridines and metabolites in rat hepatoma cells.
Carcinogenesis 6(3) , 455-7, (1985) Two closely related hepatoma cell lines were examined for their genotoxic response to benacridines and their metabolites by the appearance of alkaline labile DNA sites: H5, a dedifferentiated line expressing cytochrome P-448-dependent mono-oxygenase(s); and H... |
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Surface changes and hormone production in pituitary cells during tumorigenesis.
J. Exp. Clin. Cancer Res 18(4) , 553-8, (1999) Prolactinomas were induced by chronic estrone acetate treatment in female Wistar rats in vivo. After enzymatic dissociation of the tumor tissue, monolayer cell cultures were obtained. In vitro tumor induction was performed by treatment of normal monolayer ant... |
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Immunomodulation activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines.
Anticancer Res. 13(2) , 439-42, (1993) Some non-differentiation-induction benzo[a]phenothiazines and mutagenic benz[c]acridines more potently inhibited the mitogen-induced blast transformation of human-peripheral blood lymphocytes than differentiation-induction and non-mutagenic counterparts and p... |
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Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds.
Anticancer Res. 13(1) , 263-6, (1993) Effect of K- and L- molecular orbital regions on expression of antiplasmid and carcinogenic activity was studied with various benz[c]acridine derivatives, tricyclic compounds (acridine orange, phenothiazines) and dibenzoazepine (imipramine). Antiplasmid compo... |
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Radical intensity and carcinogenic activity of benz[c]acridines.
Anticancer Res. 17(5A) , 3553-7, (1997) Among 13 benz[c]acridines, six 7-methyl-substituted compounds (7-methylbenz[c]acridine, 7,9-dimethylbenz[c]acridine, 7,10-dimethylbenz[c]acridine, 7,11-dimethylbenz[c]acridine, 7,9,10-trimethylbenz[c]acridine, 7,9,11-trimethylbenz[c]acridine) were carcinogeni... |
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Relationship between resonance energy and carcinogenic activity of benz[c]acridines.
Anticancer Res. 12(6B) , 2105-8, (1992) In order to investigate the correlation between the carcinogenic activity of benz[c]acridines and the electron density, the Huckel orbital method was used. Resonance energies, circuit resonance energies and bond currents of benz[c]acridines were calculated by... |
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Quantumchemical structure of carcinogenic benz[c]acridines.
Anticancer Res. 14(5A) , 1811-22, (1994) Resonance energies, circuit resonance energies and bond currents of benz[c]acridines were calculated by Aihara's IRE theory. Consequently, it was shown that these compounds had very stable aromatic characters with positive resonance energies and that the reso... |
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Qualitative structure-activity relationships (QSAR) by the 1H NMR spectra of methylbenz[c]acridines.
Neoplasma 33(3) , 313-22, (1986) The 1H NMR spectra of benz[c]acridine and its methyl derivatives (BAc) in CDCl3 have been measured. The total assignment of 1H NMR spectra and spin coupling constants of BAc were discussed. The good relationship between the delta delta (delta 2--delta 1) and ... |