透明质酸酶
透明质酸酶结构式
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常用名 | 透明质酸酶 | 英文名 | hyaluronidase |
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| CAS号 | 37259-53-3 | 分子量 | N/A | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | N/A | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Faster fertilization rate in conspecific versus heterospecific matings in house mice.
Evolution 63 , 20-8, (2010) Barriers to gene flow can arise at any stage in the reproductive sequence. Most studies of reproductive isolation focus on premating or postzygotic phenotypes, leaving the importance of differences in fertilization rate overlooked. Two closely related species... |
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Diffusion Regulation in the Vitreous Humor.
Biophys. J. 109 , 2171-81, (2015) The efficient treatment of many ocular diseases depends on the rapid diffusive distribution of solutes such as drugs or drug delivery vehicles through the vitreous humor. However, this multicomponent hydrogel possesses selective permeability properties, which... |
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Insights into the mode of action of a putative zinc transporter CzrB in Thermus thermophilus.
Structure 16(9) , 1378-88, (2008) The crystal structures of the cytoplasmic domain of the putative zinc transporter CzrB in the apo and zinc-bound forms reported herein are consistent with the protein functioning in vivo as a homodimer. NMR, X-ray scattering, and size-exclusion chromatography... |
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Staphylococcus aureus hyaluronidase is a CodY-regulated virulence factor.
Infect. Immun. 82(10) , 4253-64, (2014) Staphylococcus aureus is a Gram-positive pathogen that causes a diverse range of bacterial infections. Invasive S. aureus strains secrete an extensive arsenal of hemolysins, immunomodulators, and exoenzymes to cause disease. Our studies have focused on the se... |
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Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.
Eur. J. Med. Chem. 46 , 4419-29, (2011) Bacterial hyaluronan lyases (Hyal) degrade hyaluronan, an important component of the extracellular matrix, and are involved in microbial spread. Hyal inhibitors may serve as tools to study the role of the enzyme, its substrates and products in the course of b... |
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Mechanisms involved in extracellular matrix remodeling and arterial stiffness induced by hyaluronan accumulation.
Atherosclerosis 244 , 195-203, (2016) Hyperglycemia induces hyaluronan (HA) accumulation in the vasculature. Excessive accumulation of HA around the vascular smooth muscle cells (VSMC) results in increased aortic stiffness and strength and accelerated atherosclerosis in ApoE(-)/(-) mice. We hypot... |
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Analysing mucin degradation.
Methods Mol. Biol. 842 , 191-215, (2012) Turnover of mucins in supramucosal gels is essential for the removal of surface contaminants, and the maintenance of normal mucosal barrier function. In addition to the well-known processes promoting the physical turnover of mucus gels, extracellular mucin de... |
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Hyaluronidases.
Adv. Enzymol. Relat. Subj. Biochem. 13 , 199-236, (1952)
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The formation of unsaturated disacharides from mucopoly-saccharides and their cleavage to alpha-keto acid by bacterial enzymes.
J. Biol. Chem. 235 , 3061-5, (1960)
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Catalytic mechanism of hyaluronate lyase from Streptococcus pneumonia [corrected] : quantum mechanical/molecular mechanical and density functional theory studies.
J. Phys. Chem. B 117(35) , 10161-72, (2013) Hyaluronate lyase from Spectrococcus pneumonia can degrade hyaluronic acid, which is one of the major components in the extracellular matrix. The major functions of hyaluronan are to regulate water balance and osmotic pressure and act as an ion-exchange resin... |