MethADP
MethADP结构式
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常用名 | MethADP | 英文名 | MethADP |
|---|---|---|---|---|
| CAS号 | 3768-14-7 | 分子量 | 425.22800 | |
| 密度 | 2.35g/cm3 | 沸点 | 895.6ºC at 760mmHg | |
| 分子式 | C11H17N5O9P2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 495.4ºC |
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Identification of critical ligand binding determinants in Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase.
J. Med. Chem. 52 , 5485-95, (2009) Mycobacterium tuberculosis adenosine-5'-phosphosulfate (APS) reductase is an iron-sulfur protein and a validated target to develop new antitubercular agents, particularly for the treatment of latent infection. To facilitate the development of potent and speci... |
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Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.
Immunity 38(3) , 555-69, (2013) Monocyte-derived macrophages are essential for recovery after spinal cord injury, but their homing mechanism is poorly understood. Here, we show that although of common origin, the homing of proinflammatory (M1) and the "alternatively activated" anti-inflamma... |
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Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling
Structure 20(12) , 2161-73, (2012) In vertebrates ecto-5′-nucleotidase (e5NT) catalyzes the hydrolysis of extracellular AMP to adenosine and represents the major control point for extracellular adenosine levels. Due to its pivotal role for activation of P1 adenosine receptors, e5NT has emerged... |
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Hypoxia induces adenosine release from the rat carotid body.
J. Neurochem. 89 , 1148-1156, (2004) The effect of hypoxia on the release of adenosine was studied in vitro in the rat whole carotid body (CB) and compared with the effect of hypoxia (2%, 5% and 10% O(2)) on adenosine concentrations in superior cervical ganglia (SCG) and carotid arteries. Modera... |
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IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier.
Eur. J. Immunol. 38 , 2718-2726, (2008) IFN-beta treatment reduces the relapse rate in MS but its mechanism of action remains incompletely understood. Our aim was to clarify the beneficial effect of IFN-beta in the treatment of MS. We assessed the influence of IFN-beta treatment on (i) CD73 express... |
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Altered purinergic signaling in CD73-deficient mice inhibits tumor progression.
Eur. J. Immunol. 41 , 1231-1241, (2011) CD73/ecto-5'-nucleotidase dephosphorylates extracellular AMP into adenosine, and it is a key enzyme in the regulation of adenosinergic signaling. The contribution of host CD73 to tumor growth and anti-tumor immunity has not been studied. Here, we show that un... |
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Studies of the extracellular ATP-adenosine pathway in human urinary tract epithelial cells.
Pharmacology 84 , 196-202, (2009) Extracellular ATP may be metabolized to AMP and adenosine by the ectonucleotidases CD39 and CD73 and, in this study, we characterized the pathways for adenosine formation in human urinary tract epithelial cells.Bladder (RT4) and kidney (A498) epithelial cells... |
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Magnesium reduces myocardial infarct size via enhancement of adenosine mechanism in rabbits.
Cardiovasc. Res. 54(3) , 568-75, (2002) Clinical impact of magnesium (Mg) therapy remains controversial in acute myocardial infarction. We investigated the infarct size limiting effects of Mg and its mechanism in rabbits.Anesthetized rabbits underwent 30 min coronary occlusion and 3 h reperfusion i... |
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Mechanism of hydrolysis of phosphate esters by the dimetal center of 5'-nucleotidase based on crystal structures.
J. Mol. Biol. 309(1) , 239-54, (2001) 5'-Nucleotidase belongs to a large superfamily of distantly related dinuclear metallophosphatases including the Ser/Thr protein phosphatases and purple acid phosphatases. The protein undergoes a 96 degrees domain rotation between an open (inactive) and a clos... |
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Complementary role of extracellular ATP and adenosine in ischemic preconditioning in the rat heart.
Am. J. Physiol. Heart Circ. Physiol. 282(5) , H1810-20, (2002) Although adenosine is an important mediator of ischemic preconditioning (IPC), its relative contribution to IPC remains unknown. Because adenosine is formed through the hydrolysis of ATP, the present study investigated the role of ATP and adenosine in IPC. Is... |