VIP Antagonist
VIP Antagonist结构式
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常用名 | VIP Antagonist | 英文名 | VIP Antagonist |
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| CAS号 | 125093-93-8 | 分子量 | 3467.06 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C154H257N49O40S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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VIP boosts regulatory T cell induction by trophoblast cells in an in vitro model of trophoblast-maternal leukocyte interaction.
J. Leukoc. Biol. 98 , 49-58, (2015) Inducible regulatory T cells (Tregs) exert a timely and efficient immunosuppressive action at the critical peri-implantation stage essential for maternal tolerance to the conceptus. Vasoactive intestinal peptide (VIP) promotes anti-inflammatory and tolerogeni... |
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Glucagon-like peptides 1 and 2 and vasoactive intestinal peptide are neuroprotective on cultured and mast cell co-cultured rat myenteric neurons.
BMC Gastroenterol. 12 , 30, (2012) Neuropathy is believed to be a common feature of functional and inflammatory intestinal diseases. Vasoactive intestinal peptide (VIP) is an acknowledged neuroprotective agent in peripheral, including enteric, and central neurons. The proglucagon-like hormones... |
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Vasoactive intestinal polypeptide antagonists attenuate vagally induced tachycardia in the anesthetized dog.
Am. J. Physiol. 269(4 Pt 2) , H1467-72, (1995) We used three vasoactive intestinal polypeptide (VIP) antagonists, VIP-(10-28), [p-Cl-D-Phe6,Leu17]VIP, and NT-VIP, to evaluate the role of VIP as a mediator of vagally induced tachycardia in chloralose-anesthetized dogs. After we administered muscarinic and ... |
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Inhibition of human neuroblastoma growth by a specific VIP antagonist.
J. Mol. Neurosci. 5(4) , 231-9, (1994) The 28-amino-acid neuropeptide, vasoactive intestinal peptide (VIP), is a potent mitogen during embryonic development and plays a vital role in brain growth. VIP is also mitogenic for tumor cells, including the human neuroblastoma (NMB). Northern blot analysi... |
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A vasoactive intestinal peptide antagonist inhibits the growth of glioblastoma cells.
J. Mol. Neurosci. 17(3) , 331-9, (2001) The effects of a vasoactive intestinal peptide (VIP) receptor antagonist (VIPhyb) on human glioblastoma cells were characterized. Pituitary adenylate cyclase activating polypeptide (125I-PACAP-27) bound with high affinity to U87, U118, and U373 cells. Specifi... |
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Pharmacological inhibition of VIP signaling enhances antiviral immunity and improves survival in murine cytomegalovirus-infected allogeneic bone marrow transplant recipients.
Blood 121(12) , 2347-51, (2013) Cytomegalovirus (CMV) infection following allogeneic bone marrow transplant (allo-BMT) is controlled by donor-derived cellular immunity. Vasoactive intestinal peptide (VIP) suppresses Th1 immunity. We hypothesized that blocking VIP-signaling would enhance ant... |
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VIP antagonist demonstrates differences in VIP- and PHI-mediated stimulation and inhibition of ACTH and corticosterone secretion in rats.
Regul. Pept. 59(3) , 321-33, (1995) Previous studies in our laboratory have demonstrated that PVN administration of equimolar doses of VIP and PHI induce similar increases in plasma ACTH and CORT concentrations via the release of CRF and vasopressin in fasted, freely moving rats studied during ... |
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Transmitter role of vasoactive intestinal peptide.
Pharmacol. Toxicol. 72(6) , 354-63, (1993) Vasoactive intestinal polypeptide (VIP) is a 28 amino acid with a wide-spread neuronal localization. VIP fulfils many of the classical criteria for neurotransmission. In the cerebral cortex bipolar VIP neurones are involved in the coupling between energy meta... |
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Antagonism of VIP-stimulated cyclic AMP formation in chick brain.
J. Mol. Neurosci. 20(2) , 163-72, (2003) Of eight peptides tested (0.01-5 microM), only two, that is, pituitary adenylate cyclase-activating polypeptide (PACAP27) and chicken vasoactive intestinal peptide (cVIP), potently stimulated cyclic AMP (cAMP) production in cerebral cortical slices of the chi... |
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Vasoactive intestinal peptide-stimulated adenosine 3',5'-cyclic monophosphate formation in cerebral cortex and hypothalamus of chick and rat: comparison of the chicken and mammalian peptide.
Neurosci. Lett. 297(2) , 93-6, (2001) Chicken and mammalian (human/porcine/rat) vasoactive intestinal peptides (VIP; 0.01-3 microM), whose structures differ by four amino acid residues in 11, 13, 26 and 28 positions, were compared with respect to their ability to stimulate adenosine 3',5'-cyclic ... |