NG,NG ′-二甲基-L-精氨酸 二(对羟基偶氮苯对磺酸) 盐
NG,NG ′-二甲基-L-精氨酸 二(对羟基偶氮苯对磺酸) 盐结构式
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常用名 | NG,NG ′-二甲基-L-精氨酸 二(对羟基偶氮苯对磺酸) 盐 | 英文名 | NG,NGμ-Dimethyl-L-arginine di(p-hydroxyazobenzene-pμ-sulfonate) salt |
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| CAS号 | 1266235-58-8 | 分子量 | 758.82 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C32H38N8O10S2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.
J. Biol. Chem. 290 , 16723-43, (2015) Human protein arginine methyltransferase (PRMT) 9 symmetrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally linked to the regulation of alternative splicing of pre-mRNA. Site-directed mutagenesis studies on this ... |
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PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145.
Nat. Commun. 6 , 6428, (2015) The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two spliceosome-associated proteins-SAP145 and SAP49-as PRMT9-bindin... |
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Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.
J. Pharm. Pharm. Sci. 17(4) , 475-84, (2015) Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a major impact on the hepatic clearance of drugs. The effect of d... |
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Digital plethysmography and arginine metabolism in prehypertension: effect of nebivolol therapy.
J. Clin. Hypertens. (Greenwich.) 17(1) , 14-9, (2015) Prehypertension is an important phenotype for cardiovascular risk and development of established hypertension. To better understand the early circulatory changes in this group, the authors studied 34 patients with prehypertension (blood pressure 120-139/80-89... |
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Quantification of arginine and its methylated derivatives in healthy children by liquid chromatography-tandem mass spectrometry.
J. Chromatogr. Sci. 53 , 787-92, (2015) Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of nitric oxide synthase, which is responsible for most of the vascular nitric oxide (NO) produced. NO is an important physiological mediator of vascular tone and structure in normally functioning ... |
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Serum homocysteine, asymmetric dimethyl arginine (ADMA) and other arginine-NO pathway metabolite levels in patients with psoriasis.
Arch. Dermatol. Res. 307 , 439-44, (2015) Hyperhomocysteinemia, a well-known and independent risk factor for cardiovascular disease, has been related in several studies with psoriasis patients. It has been suggested that homocysteine leads to endothelial dysfunction by causing an accumulation of asym... |
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Comparison of serum concentrations of symmetric dimethylarginine and creatinine as kidney function biomarkers in healthy geriatric cats fed reduced protein foods enriched with fish oil, L-carnitine, and medium-chain triglycerides.
Vet. J. 202(3) , 588-96, (2014) The purpose of this study was to determine whether feeding cats reduced protein and phosphorus foods with added fish oil, L-carnitine, and medium-chain triglycerides (MCT) altered serum biomarkers of renal function. Thirty-two healthy cats, mean age 14.0 (8.3... |
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Optimization of the separation of NDA-derivatized methylarginines by capillary and microchip electrophoresis.
J. Lab. Autom. 17(1) , 24-31, (2012) The methylated arginines (MAs) monomethylarginine (MMA), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) have been shown to be independent predictors of cardiovascular disease. This article describes progress regarding the developmen... |
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Time course of asymmetric dimethylarginine and symmetric dimethylarginine levels after successful renal transplantation.
Nephrol. Dial. Transplant. 29(10) , 1965-72, (2014) Although renal transplantation (Tx) improves the outcome of patients with renal disease, cardiovascular (CV) risk remains high. Recently, it was demonstrated that asymmetric dimethylarginine (ADMA) levels predict CV events and graft survival in renal transpla... |
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Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART.
J. Acquir. Immune Defic. Syndr. 67(4) , 370-4, (2014) Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.In 60 HIV-infect... |