Ac-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-Gln-OH游离态
Ac-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-Gln-OH游离态结构式
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常用名 | Ac-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-Gln-OH游离态 | 英文名 | Acetyl-Hirudin (55-65) (desulfated) |
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| CAS号 | 113274-57-0 | 分子量 | 1453.50000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C66H92N12O25 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
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Lepirudin blunts endotoxin-induced coagulation activation.
Blood 95 , 1729-1734, (2000) During sepsis, lipopolysaccharide (LPS) triggers the development of disseminated intravascular coagulation (DIC) via the tissue factor-dependent pathway of coagulation resulting in massive thrombin generation and fibrin polymerization. Recently, animal studie... |
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Thrombin-dependent MMP-2 activity is regulated by heparan sulfate.
J. Biol. Chem. 285 , 41270-41279, (2010) Like most metalloproteases, matrix metalloprotease 2 (MMP-2) is synthesized as a zymogen. MMP-2 propeptide plays a role in inhibition of catalytic activity through a cysteine-zinc ion pairing, disruption of which results in full enzyme activation. A variety o... |
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Chemical compensation in macromolecular bridge-binding to thrombin.
Biochemistry 32 , 2947-2953, (1993) The binding energetics of eight synthetic peptides capable of interfering with thrombin function have been studied by steady-state measurements and clotting assays. The synthetic peptides are bifunctional inhibitors consisting of three domains: (i) a fragment... |
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N-terminal requirements of small peptide anticoagulants based on hirudin 54-65. Owen TJ, Krstenansky JL, et al.
J. Med. Chem. 32 , 1009-1011, (1988)
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