DL-丙氨酰基-DL-苯丙氨酸
DL-丙氨酰基-DL-苯丙氨酸结构式
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常用名 | DL-丙氨酰基-DL-苯丙氨酸 | 英文名 | H-DL-Ala-DL-Phe-OH |
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| CAS号 | 1999-45-7 | 分子量 | 236.26700 | |
| 密度 | 1.222 g/cm3 | 沸点 | 487.6ºC at 760 mmHg | |
| 分子式 | C12H16N2O3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 248.7ºC |
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Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.
Nat. Chem. Biol. 5 , 45-52, (2009) Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting transceptors is unknown. We have screened 319 amino acid anal... |
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Separation of N-derivatized di- and tri-peptide stereoisomers by micro-liquid chromatography using a quinidine-based monolithic column - Analysis of l-carnosine in dietary supplements.
J. Chromatogr. A. 1428 , 176-84, (2016) In the present study, a new analytical methodology was developed enabling the enantiomeric determination of N-derivatized di- and tri-peptides in dietary supplements using chiral micro-LC on a monolithic column consisting of poly(O-9-[2-(methacryloyloxy)-ethy... |
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Estimation of the pH-independent binding constants of alanylphenylalanine and leucylphenylalanine stereoisomers with beta-cyclodextrin in the presence of urea.
Electrophoresis 20(1) , 171-9, (1999) The separation of stereoisomers, particularly enantiomers, is important when their physiological activity differs. We have resolved the four stereoisomers each of alanylphenylalanine (Ala-Phe) and of leucylphenylalanine (Leu-Phe) by capillary electrophoresis ... |
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Alkali metal complexes of the dipeptides PheAla and AlaPhe: IRMPD spectroscopy.
ChemPhysChem 9 , 579-589, (2008) Complexes of PheAla and AlaPhe with alkali metal ions Na(+) and K(+) are generated by electrospray ionization, isolated in the Fourier-transform ion cyclotron resonance (FT-ICR) ion trapping mass spectrometer, and investigated by infrared multiple-photon diss... |
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Single-conformation ultraviolet and infrared spectroscopy of model synthetic foldamers: beta-peptides Ac-beta3-hPhe-beta3-hAla-NHMe and Ac-beta3-hAla-beta3-hPhe-NHMe.
J. Am. Chem. Soc. 130(14) , 4795-807, (2008) The conformational preferences and infrared and ultraviolet spectral signatures of two model beta-peptides, Ac-beta3-hPhe-beta3-hAla-NHMe (1) and Ac-beta3-hAla-beta3-hPhe-NHMe (2), have been explored under jet-cooled, isolated-molecule conditions. The mass-re... |
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Simultaneous determination of Angiotensin I-converting enzyme inhibitory peptides in tryptic casein hydrolysate by high-performance liquid chromatography combined with a replicate heart-cut column-switching technique.
J. Agric. Food Chem. 55(21) , 8367-71, (2007) A replicate heart-cut column-switching HPLC method combined with two switching valves was newly developed for the simultaneous determination of three antihypertensive peptides (Ala-Phe, Tyr-Pro, and Trp-Tyr) in tryptic casein hydrolysate in one run-in assay. ... |
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Computed and experimental chemical shift parameters for rigid and flexible YAF peptides in the solid state.
J. Phys. Chem. B 116(6) , 1974-83, (2012) DFT methods were employed to compute the (13)C NMR chemical shift tensor (CST) parameters for crystals of YAF peptides (Tyr-Ala-Phe) with different stereochemistry for the Ala residue. Tyr-D-Ala-Phe 1 crystallizes in the C2 space group while Tyr-L-Ala-Phe cry... |
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Chiral separation based on ligand-exchange capillary electrophoresis using a copper(II)-L-ornithine ternary complex as selector.
Electrophoresis 26(4-5) , 1007-12, (2005) A ligand-exchange capillary electrophoresis was explored, with L-ornithine as the ligand and copper(II) as the central ion. Its applicability was demonstrated with underivatized and dansyl amino acids, a dipeptide, and drugs with amino alcohol structure. The ... |
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Structural and enzymatic characterization of BacD, an L-amino acid dipeptide ligase from Bacillus subtilis.
Protein Sci. 21(5) , 707-16, (2012) BacD is an ATP-dependent dipeptide ligase responsible for the biosynthesis of L-alanyl-L-anticapsin, a precursor of an antibiotic produced by Bacillus spp. In contrast to the well-studied and phylogenetically related D-alanine: D-alanine ligase (Ddl), BacD sy... |
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Structure-based design of residue 1 analogs of the direct thrombin inhibitor pentapeptide FM 19.
Chem. Biol. Drug Des. 75(1) , 35-9, (2010) Myocardial ischemia and other acute coronary syndromes are leading causes of death worldwide, and often result from a thrombus that blocks an atherosclerotic coronary artery. A key enzyme in thrombus formation is the serine protease thrombin, which is respons... |