二氢乙锭
二氢乙锭结构式
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常用名 | 二氢乙锭 | 英文名 | Dihydroethidium |
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| CAS号 | 104821-25-2 | 分子量 | 315.411 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 580.4±50.0 °C at 760 mmHg | |
| 分子式 | C21H21N3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 299.5±24.9 °C |
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High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10.
Microb. Cell Fact. 13 , 163, (2015) The yeast Pichia pastoris (P. pastoris) has become a popular 'cell factory' for producing heterologous proteins, but production widely varies among proteins. Cultivation temperature is frequently reported to significantly affect protein production; however, t... |
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A yeast model of the Parkinson's disease-associated protein Parkin.
Exp. Cell Res. 333(1) , 73-9, (2015) Mutations in Parkin, an E3 ubiquitin ligase, are associated to autosomal recessive Parkinson's disease (PD). Parkin has been mainly implicated, along with Pink1, in mitochondrial autophagy in response to stress. In this study, a yeast model was developed to a... |
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Auranofin induces apoptosis and necrosis in HeLa cells via oxidative stress and glutathione depletion.
Mol. Med. Report. 11(2) , 1428-34, (2014) Auranofin (Au), an inhibitor of thioredoxin reductase, is a known anti‑cancer drug. In the present study, the anti‑growth effect of Au on HeLa cervical cancer cells was examined in association with levels of reactive oxygen species (ROS) and glutathione (GSH)... |
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Superparamagnetic iron oxide nanoparticles exacerbate the risks of reactive oxygen species-mediated external stresses.
Arch. Toxicol. 89(3) , 357-69, (2015) Superparamagnetic iron oxide nanoparticles (IONPs) have been widely applied in numerous biomedical fields. The evaluation of the toxicity of IONPs to the environment and human beings is indispensable to guide their applications. IONPs are usually considered t... |
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Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.
J. Neuropathol. Exp. Neurol. 74 , 1093-118, (2015) Despite effective viral suppression through combined antiretroviral therapy (cART), approximately half of HIV-positive individuals have HIV-associated neurocognitive disorders (HAND). Studies of antiretroviral-treated patients have revealed persistent white m... |
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A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3.
Mol. Cell. Biol. 35 , 3646-56, (2015) Increased production of mitochondrion-derived reactive oxygen species (ROS) is characteristic of a metabolic shift observed during malignant transformation. While the exact sources and roles of ROS in tumorigenesis remain to be defined, it has become clear th... |
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Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1.
J. Virol. 89(4) , 2268-86, (2015) Nuclear factor erythroid 2-related factor 2 (Nrf2), the cellular master regulator of the antioxidant response, dissociates from its inhibitor Keap1 when activated by stress signals and participates in the pathogenesis of viral infections and tumorigenesis. Ea... |
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Evaluation of cytotoxic activity of titanocene difluorides and determination of their mechanism of action in ovarian cancer cells.
Invest. New Drugs 33 , 1123-32, (2015) Ovarian cancer is the seventh-most common cancer amongst women and the most deadly gynecologic cancer. Cisplatin based drugs are used in first line therapy, but resistance represents a major obstacle for successful treatment. In this study, we investigated th... |
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A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling.
PLoS ONE 10 , e0137106, (2015) Oxidative stress has been implicated in cardiac remodeling (cardiac fibrosis and hypertrophy), which impairs cardiac function and metabolism; therefore, it is anticipated antioxidative compounds will have protective properties against cardiac remodeling. Lute... |
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Melatonin prevents neural tube defects in the offspring of diabetic pregnancy.
J. Pineal Res. 59 , 508-17, (2015) Melatonin, an endogenous neurohormone secreted by the pineal gland, has a variety of physiological functions and neuroprotective effects. However, its protective role on the neural tube defects (NTDs) was not very clear. The aim of this study was to investiga... |