对三氟甲基水杨酸
对三氟甲基水杨酸结构式
|
常用名 | 对三氟甲基水杨酸 | 英文名 | 4-Trifluoromethylsalicylic acid |
|---|---|---|---|---|
| CAS号 | 328-90-5 | 分子量 | 206.119 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 286.4±40.0 °C at 760 mmHg | |
| 分子式 | C8H5F3O3 | 熔点 | 178ºC | |
| MSDS | 美版 | 闪点 | 127.0±27.3 °C |
|
The study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods.
Eur. J. Pharm. Sci. 31(3-4) , 211-20, (2007) In this research, the effects of micellar systems on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) were found to be dependant upon the surfactant charge within the micelle. In cationic micelles, there is a catalytic effect at... |
|
|
A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers.
Expert Opin. Drug Metab. Toxicol. 7(12) , 1471-9, (2011) An enteric-coated formulation of triflusal (triflusal EC), an antiplatelet agent, was developed to reduce the high incidence of gastrointestinal adverse events (AEs). The aim of this study is to compare the pharmacokinetics, pharmacodynamics and safety of tri... |
|
|
Salicylates increase insulin secretion in healthy obese subjects.
J. Clin. Endocrinol. Metab. 93(7) , 2523-30, (2008) Conflicting results on the effects of salicylates on glucose tolerance in subjects with normal glucose tolerance or type 2 diabetes have been reported.The objective of the study was to investigate the effects of a salicylate derivative (triflusal) on insulin ... |
|
|
Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2.
J. Thromb. Haemost. 6(8) , 1385-92, (2008) Carotid residual mural thrombus predisposes to recurrent thrombosis and/or distal embolization (i.e. cerebrovascular ischemia).Our aims were (i) to analyze and compare the efficacy of aspirin, triflusal, and its main metabolite 2-hydroxy-4-trifluorometylbenzo... |
|
|
Photonucleophilic addition of the epsilon-amino group of lysine to a triflusal metabolite as a mechanistic key to photoallergy mediated by the parent drug.
ChemMedChem 4(7) , 1196-202, (2009) A mechanism for triflusal-induced photoallergy involving complexation of 2-hydroxy-4-trifluoromethylbenzoic acid with site I of human serum albumin and subsequent formation of a covalent adduct by photoreaction between a metabolite and a neighboring lysine re... |
|
|
Simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 798(2) , 257-64, (2003) A rapid, selective and sensitive high-performance liquid chromatography (HPLC) method was developed and validated for the simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), in rat and human... |
|
|
Photochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal.
Photochem. Photobiol. 73(5) , 463-8, (2001) Triflusal is a platelet antiaggregant drug with photoallergic side effects. However, it is considered a prodrug since it is metabolized to 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)--the pharmacologically active form. HTB was found to be photolabile under ... |
|
|
Pharmacokinetics of triflusal after single and repeated doses in man.
Int. J. Clin. Pharmacol. Ther. Toxicol. 28(8) , 344-9, (1990) Triflusal pharmacokinetics were evaluated in 8 healthy subjects after a single 300 mg dose and after repeated doses of 300 mg every 8 h and 600 mg every 24 h during 13 days, with the aim of establishing a relationship between plasma levels and dosage patterns... |
|
|
Binding of a metabolite of triflusal (2-hydroxy-4-trifluoromethylbenzoic acid) to serum proteins in rat and man.
Eur. J. Clin. Pharmacol. 42(2) , 175-9, (1992) 2-hydroxy-4-trifluoromethylbenzoic acid (HTB) is the main active metabolite of the platelet antiaggregant drug triflusal. Its binding to plasma proteins of rats and healthy volunteers in vitro and in vivo has been studied. Rats were given a single oral dose o... |
|
|
Protective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids.
Naunyn Schmiedebergs Arch. Pharmacol. 371(1) , 81-8, (2005) Triflusal is a fluorinated derivative of acetylsalicylic acid (ASA) with demonstrated antithrombotic activity. Recently, evidence for a neuroprotective effect has been obtained. The aim of this study was to compare the neuroprotective effects of the main meta... |