DL-高苯丙氨酸
DL-高苯丙氨酸结构式
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常用名 | DL-高苯丙氨酸 | 英文名 | DL-Homophenylalanine |
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| CAS号 | 1012-05-1 | 分子量 | 179.216 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 324.8±35.0 °C at 760 mmHg | |
| 分子式 | C10H13NO2 | 熔点 | 282ºC (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 150.2±25.9 °C |
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Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
Biotechnol. Bioeng. 102(5) , 1323-9, (2009) 2-Phenylethanol is a widely used aroma compound with rose-like fragrance and L-homophenylalanine is a building block of angiotensin-converting enzyme (ACE) inhibitor. 2-phenylethanol and L-homophenylalanine were synthesized simultaneously with high yield from... |
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Glyphosate suppresses the antagonistic effect of Enterococcus spp. on Clostridium botulinum.
Bioorg. Med. Chem. Lett. 16 , 1138-41, (2006) During the last 10-15 years, an increase of Clostridium botulinum associated diseases in cattle has been observed in Germany. The reason for this development is currently unknown. The normal intestinal microflora is a critical factor in preventing intestinal ... |
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Opening of Iris flowers is regulated by endogenous auxins.
J. Plant Physiol. 170(2) , 161-4, (2013) Flower opening in Iris (Iris×hollandica) requires elongation of the pedicel and ovary. This moves the floral bud upwards, thereby allowing the tepals to move laterally. Flower opening is requires with elongation of the pedicel and ovary. In cv. Blue Magic, we... |
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Benzyladenine metabolism and temporal competence of Pinus pinea cotyledons to form buds in vitro.
J. Plant Physiol. 166(10) , 1069-76, (2009) Germination negatively affects adventitious shoot formation induced by cytokinins in pine cotyledons. To investigate the causes of this decrease in the organogenic response, uptake and metabolism of benzyladenine (BA) were studied in stone pine cotyledons (Pi... |
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The design of potent and selective inhibitors of DPP-4: Optimization of ADME properties by amide replacements
Bioorg. Med. Chem. Lett. 19(22) , 6340-5, (2009) For a series of β-homophenylalanine based inhibitors of dipeptidyl peptidase IV ADME properties were improved by the incorporation of amide replacements. These efforts led to a novel series of potent and selective inhibitors of DPP-4 that exhibit an attractiv... |
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Synthesis and immunosuppressive activity of cyclolinopeptide A analogues containing homophenylalanine.
Eur. J. Med. Chem. 44(9) , 3731-8, (2009) Immune response suppressors are used in the medical praxis to prevent graft rejection after organ transplantation and in the therapy of some autoimmune diseases. Cyclolinopeptide A, naturally existing immunomodulatory peptide, was modified with homophenylalan... |
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Identification of potent 11mer glucagon-like peptide-1 receptor agonist peptides with novel C-terminal amino acids: Homohomophenylalanine analogs.
Peptides 31(5) , 950-5, (2010) We report the identification of potent agonists of the Glucagon-Like Peptide-1 Receptor (GLP-1R). These compounds are short, 11 amino acid peptides containing several unnatural amino acids, including (in particular) analogs of homohomophenylalanine (hhPhe) at... |
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Asymmetrically simultaneous synthesis of L-homophenylalanine and N6-protected-2-oxo-6-amino-hexanoic acid by engineered Escherichia coli aspartate aminotransferase.
Biotechnol. Prog. 25(6) , 1637-42, (2009) L-Homophenylalanine (L-HPA) and N(6)-protected-2-oxo-6-amino-hexanoic acid (N(6)-protected-OAHA) can be used as building blocks for the manufacture of angiotensin-converting enzyme inhibitors. To synthesize L-HPA and N(6)-protected-OAHA simultaneously from 2-... |
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From lead to preclinical candidate: optimization of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV.
Bioorg. Med. Chem. Lett. 19(16) , 4818-23, (2009) A series of highly potent and selective inhibitors of DPP-4 was optimized for ADMET properties. The effort resulted in the discovery of inhibitor 1g, that exhibits excellent efficacy in an oral glucose tolerance test and an attractive pharmacokinetic profile. |
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Structural-functional changes in detached cucumber leaves, and modelling these by hormone-treated leaf discs.
Plant Biol. (Stuttg.) 9(1) , 85-92, (2007) Senescence and rejuvenation were investigated in detached cucumber (Cucumis sativus L.) leaves after cultivation in nutrient solution for one week or four weeks. Rooting of the petiole (visible generally from the 7th day) elicited a combination of different m... |