5-孕烷-3β-醇-20-酮-16Alpha-腈
5-孕烷-3β-醇-20-酮-16Alpha-腈结构式
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常用名 | 5-孕烷-3β-醇-20-酮-16Alpha-腈 | 英文名 | Pregnenolone 16α-carbonitrile |
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| CAS号 | 1434-54-4 | 分子量 | 341.487 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 508.5±50.0 °C at 760 mmHg | |
| 分子式 | C22H31NO2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 261.3±30.1 °C |
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Pregnane X receptor agonists impair postprandial glucose tolerance.
Clin. Pharmacol. Ther. 93(6) , 556-63, (2013) We conducted a randomized, open, placebo-controlled crossover trial to investigate the effects of the pregnane X receptor (PXR) agonist rifampin on an oral glucose tolerance test (OGTT) in 12 healthy volunteers. The subjects were administered 600 mg rifampin ... |
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The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers.
Toxicol. Appl. Pharmacol. 272(1) , 172-9, (2013) The cytochrome P450 (CYP) 2 gene family is the largest and most diverse CYP gene family in vertebrates. In zebrafish, we have identified 10 genes in a new subfamily, CYP2AA, which does not show orthology to any human or other mammalian CYP genes. Here we repo... |
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Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Toxicol. Lett. 188(1) , 38-44, (2009) Myeloid cell leukemia-1 (Mcl-1) is an anti-apoptotic protein that is regulated by the constitutive androstane receptor (CAR). Activation of CAR can protect the liver against bile acid-induced toxicity and it may have a role in cell death via apoptosis by alte... |
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Assessment of cytochrome P450 fluorometric substrates with rainbow trout and killifish exposed to dexamethasone, pregnenolone-16alpha-carbonitrile, rifampicin, and beta-naphthoflavone.
Aquat. Toxicol. 97 , 324-333, (2010) Cytochrome P450s (CYPs) are important xenobiotic metabolizing proteins. While their functions are well understood in mammals, CYP function in non-mammalian vertebrate systems is much less defined, with function often inferred from mammalian data, assuming sim... |
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A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile.
PLoS ONE 6(2) , e16703, (2011) The nuclear receptor superfamily of ligand-activated transcription factors plays a central role in the regulation of cellular responses to chemical challenge. Nuclear receptors are activated by a wide range of both endogenous and exogenous chemicals, and thei... |
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Organic anion transporting polypeptide 2-mediated uptake of paclitaxel and 2'-ethylcarbonate-linked paclitaxel in freshly isolated rat hepatocytes.
J. Pharm. Pharmacol. 61(8) , 1029-35, (2009) The P-glycoprotein (P-gp) efflux pump plays an important role in paclitaxel detoxification. However, hepatic uptake of paclitaxel mediated by a solute-linked carrier transporter family is still poorly understood in animals and humans. Freshly isolated hepatoc... |
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Role of UDP-glucuronosyltransferase (UGT) 2B2 in metabolism of triiodothyronine: effect of microsomal enzyme inducers in Sprague Dawley and UGT2B2-deficient Fischer 344 rats.
Toxicol. Sci. 116(2) , 413-21, (2010) Microsomal enzyme inducers (MEI) that increase UDP-glucuronosyltransferases (UGTs) can impact thyroid hormone homeostasis in rodents. Increased glucuronidation can result in reduction of serum thyroid hormone and a concomitant increase in thyroid-stimulating ... |
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Effect of lipopolysaccharide on the xenobiotic-induced expression and activity of hepatic cytochrome P450 in mice.
Biol. Pharm. Bull. 35(4) , 473-80, (2012) Infection-associated inflammation can alter the expression levels and functions of cytochrome P450s (CYPs). Cyp gene expression is regulated by the activation of several nuclear receptors, including pregnane X receptor (PXR), constitutive androstane receptor ... |
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The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver.
Drug Metab. Dispos. 38(7) , 1177-82, (2010) Mouse CYP2C55 has been characterized as an enzyme that catalyzes synthesis of 19-hydroxyeicosatetraenoic acid (19-HETE), an arachidonic acid metabolite known to have important physiological functions such as regulation of renal vascular tone and ion transport... |
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The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver.
Mol. Endocrinol. 26(6) , 916-25, (2012) The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a broad-specificity nuclear hormone receptor that is well known for its role in drug and xenobiotic metabolism. SXR is activated by a wide variety of endobiotics, dietary ... |