格列吡嗪
格列吡嗪结构式
|
常用名 | 格列吡嗪 | 英文名 | Glipizide |
|---|---|---|---|---|
| CAS号 | 29094-61-9 | 分子量 | 445.535 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 676.0±65.0 °C at 760 mmHg | |
| 分子式 | C21H27N5O4S | 熔点 | 208-209°C | |
| MSDS | 美版 | 闪点 | 362.6±34.3 °C |
|
Identification of CYP3A7 for glyburide metabolism in human fetal livers.
Biochem. Pharmacol. 92(4) , 690-700, (2014) Glyburide is commonly prescribed for the treatment of gestational diabetes mellitus; however, fetal exposure to glyburide is not well understood and may have short- and long-term consequences for the health of the child. Glyburide can cross the placenta; feta... |
|
|
Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age.
J. Pharmacol. Exp. Ther. 350(2) , 425-34, (2014) Gestational diabetes mellitus is a major complication of human pregnancy. The oral clearance (CL) of glyburide, an oral antidiabetic drug, increases 2-fold in pregnant women during late gestation versus nonpregnant controls. In this study, we examined gestati... |
|
|
Quantitative determination of metformin, glyburide and its metabolites in plasma and urine of pregnant patients by LC-MS/MS.
Biomed. Chromatogr. 29(4) , 560-9, (2015) This report describes the development and validation of an LC-MS/MS method for the quantitative determination of glyburide (GLB), its five metabolites (M1, M2a, M2b, M3 and M4) and metformin (MET) in plasma and urine of pregnant patients under treatment with ... |
|
|
Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis.
Oncotarget 5(20) , 9966-79, (2014) Angiogenesis is involved in the development, progression and metastasis of various human cancers. Herein, we report the discovery of glipizide, a widely used drug for type 2 diabetes mellitus, as a promising anticancer agent through the inhibition of tumor an... |
|
|
Glimepiride reduces CD14 expression and cytokine secretion from macrophages.
J. Neuroinflammation 11 , 115, (2014) Activated microglia are associated with deposits of aggregated proteins within the brains of patients with Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases. Since the cytokines secreted from activated microglia are thought to contribute t... |
|
|
Bioequivalence Comparison of Two Formulations of Fixed-Dose Combination Glimepiride/Metformin (2/500 mg)Tablets in Healthy Volunteers.
Iran. J. Pharm. Res. 13(2) , 365-71, (2014) Glimepiride/metformin (2/500 mg) is an oral antihyperglycemic agent for the treatment of type 2 diabetes. A generic glimepiride/metformin (2/500 mg) fixed-dose combination (FDC) tablet was developed recently. This study was designed to collect data for submis... |
|
|
Antidiabetic potential of triterpenoid saponin isolated from Primula denticulate.
Pharm. Biol. 52(6) , 750-5, (2014) Primula denticulate Sm. (Primulaceae), commonly known as drumstick primula, is traditionally used to treat diabetes and urinary disorders. In the present study, a new triterpenoid saponin was isolated. Triterpenoids generally show antidiabetic activity. Consi... |
|
|
A rapid and simple UPLC-MS-MS method for determination of glipizide in human plasma and its application to bioequivalence study.
J. Chromatogr. Sci. 53(1) , 85-9, (2014) In this study, a simple, rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry method is described for the determination of glipizide in human plasma samples using carbamazepine as the internal standard (IS) from bioequivalence ... |
|
|
Coadministration of co-trimoxazole with sulfonylureas: hypoglycemia events and pattern of use.
J. Gerontol. A. Biol. Sci. Med. Sci. 70(2) , 247-54, (2015) Coadministration of co-trimoxazole with sulfonylureas is reported to increase the risk of hypoglycemia.We identified a cohort of Medicare beneficiaries aged 66 years or older who took glyburide or glipizide for diabetes from a 5% national sample of Medicare P... |
|
|
Glyburide and glipizide, second-generation oral sulfonylurea hypoglycemic agents.
Clin. Pharm. 3(5) , 473-85, (1984) The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of glyburide and glipizide, two second-generation oral sulfonylurea hypoglycemic agents, are reviewed. Glyburide and glipizide are well absorbed after oral administr... |