NG-羟基-L-精氨酸 乙酸盐
NG-羟基-L-精氨酸 乙酸盐结构式
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常用名 | NG-羟基-L-精氨酸 乙酸盐 | 英文名 | h-arg(oh)-oh acoh |
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| CAS号 | 53598-01-9 | 分子量 | 250.25200 | |
| 密度 | N/A | 沸点 | 441.4ºC at 760 mmHg | |
| 分子式 | C8H18N4O5 | 熔点 | 185.00ºC to 200.00ºC | |
| MSDS | 中文版 美版 | 闪点 | 220.8ºC |
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Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate.
J. Biol. Chem. 268 , 14781, (1993) Brain NO (nitric oxide) synthase contains FAD, FMN, heme, and tetrahydrobiopterin as prosthetic groups and represents a multi-functional oxidoreductase catalyzing oxidation of L-arginine to NO and L-citrulline, formation of H2O2, and reduction of cytochrome c... |
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Hydrogen peroxide-supported oxidation of NG-hydroxy-L-arginine by nitric oxide synthase.
Biochemistry 34 , 1930, (1995) The ability of murine macrophage nitric oxide synthase (NOS) to utilize peroxides in place of O2 and NADPH was investigated using hydrogen peroxide (H2O2), tert-butylhydroperoxide, and cumene hydroperoxide with both L-arginine and NG-hydroxy-L-arginine (L-NHA... |
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Characteristics of the nitric oxide synthase-catalyzed conversion of arginine to N-hydroxyarginine, the first oxygenation step in the enzymic synthesis of nitric oxide.
J. Biol. Chem. 270 , 1721, (1995) The nitric oxide synthase-catalyzed conversion of L-arginine to L-citrulline and nitric oxide is known to be the sum of two partial reactions: oxygenation of arginine to N-hydroxyarginine, followed by oxygenation of N-hydroxyarginine to citrulline and nitric ... |
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Arginase inhibition prevents inflammation and remodeling in a guinea pig model of chronic obstructive pulmonary disease.
J. Pharmacol. Exp. Ther. , (2014) Airway inflammation and remodeling are major features of chronic obstructive pulmonary disease (COPD), whereas pulmonary hypertension is a common comorbidity associated with a poor disease prognosis. Recent studies in animal models have indicated that increas... |
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N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase.
Biochem. Biophys. Res. Commun. 203 , 1614, (1994) N omega-Hydroxy-L-arginine (L-NOHA) is a potent inhibitor of the hydrolysis of L-arginine (L-Arg) to L-ornithine (L-Orn) catalyzed by purified bovine liver arginase (BLA). It appears as one of the most powerful arginase inhibitors reported so far (Ki = 150 mi... |
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Inhibition of rat liver arginase by an intermediate in NO biosynthesis, NG-hydroxy-L-arginine: implications for the regulation of nitric oxide biosynthesis by arginase.
Biochem. Biophys. Res. Commun. 202 , 174, (1994) NG-hydroxy-L-arginine, an intermediate in the biosynthesis of nitric oxide (NO), has been found to be a uniquely potent competitive inhibitor of rat liver arginase. Among previously reported inhibitors of arginase and the eight arginine analogs tested herein,... |