消旋甲酪氨酸
消旋甲酪氨酸结构式
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常用名 | 消旋甲酪氨酸 | 英文名 | a-methyl-D-tyrosine |
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| CAS号 | 658-48-0 | 分子量 | 195.215 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 383.7±32.0 °C at 760 mmHg | |
| 分子式 | C10H13NO3 | 熔点 | >300ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 185.9±25.1 °C |
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Contribution of dopamine to mitochondrial complex I inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice.
Neuropharmacology 93 , 124-33, (2015) Methylenedioxymethamphetamine (MDMA) causes a persistent loss of dopaminergic cell bodies in the substantia nigra of mice. Current evidence indicates that MDMA-induced neurotoxicity is mediated by oxidative stress probably due to the inhibition of mitochondri... |
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Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex.
Neuropharmacology 89 , 204-14, (2014) FADD is a crucial adaptor of death receptors that can engage apoptosis or survival actions (e.g. neuroplasticity) through its phosphorylated form (p-FADD). Although FADD was shown to participate in receptor mechanisms related to drugs of abuse, little is know... |
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Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice.
Endocrinology 156 , 2470-81, (2015) Fibroblast growth factor 21 (FGF21) has multiple metabolic actions, including the induction of browning in white adipose tissue. Although FGF21 stimulated browning results from a direct interaction between FGF21 and the adipocyte, browning is typically associ... |
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Role of brainstem serotonin in analgesia produced by low-intensity exercise on neuropathic pain after sciatic nerve injury in mice.
Pain 156 , 2595-606, (2015) Physical exercise is a low-cost, safe, and efficient intervention for the reduction of neuropathic chronic pain in humans. However, the underlying mechanisms for how exercise reduces neuropathic pain are not yet well understood. Central monoaminergic systems ... |
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Effects of intratumoral inflammatory process on 18F-FDG uptake: pathologic and comparative study with 18F-fluoro-α-methyltyrosine PET/CT in oral squamous cell carcinoma.
J. Nucl. Med. 56(1) , 16-21, (2015) The accurate depiction of both biologic and anatomic profiles of tumors has long been a challenge in PET imaging. An inflammation, which is innate in the carcinogenesis of oral squamous cell carcinoma (OSCC), frequently complicates the image analysis because ... |
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Nerve regeneration restores supraspinal control of bladder function after complete spinal cord injury.
J. Neurosci. 33(26) , 10591-606, (2013) A life-threatening disability after complete spinal cord injury is urinary dysfunction, which is attributable to lack of regeneration of supraspinal pathways that control the bladder. Although numerous strategies have been proposed that can promote the regrow... |
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The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.
Croat. Med. J. 53(3) , 214-23, (2012) To elucidate the involvement of noradrenergic system in the mechanism by which diazepam suppresses basal hypothalamic-pituitary-adrenal (HPA) axis activity.Plasma corticosterone and adrenocorticotropic hormone (ACTH) levels were determined in female rats trea... |
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Pharmacological mechanisms of antidepressant-like effect of tipepidine in the forced swimming test
Behav. Brain Res. 226(2) , 381-5, (2012) Highlights ► Tipepidine produces an antidepressant like effect in the forced swimming test. ► The effect of tipepidine may be produced via dopamine D 1 and alpha2 adrenoceptor. ► The properties of the effect may be different from those of known antidepressant... |
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AMPA glutamate receptors mediate the antidepressant-like effects of N-acetylcysteine in the mouse tail suspension test.
Behav. Pharmacol. 23(2) , 171-7, (2012) The aim of this study was to investigate the involvement of noradrenaline, serotonin, and subtypes of glutamate receptors in the antidepressant-like effects of N-acetylcysteine (NAC). The tail suspension test was used with male CF1 albino mice. D,L-α-methyl-ρ... |
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VEGF-induced antidepressant effects involve modulation of norepinephrine and serotonin systems.
Behav. Brain Res. 275 , 107-13, (2014) Throughout life, we are exposed to a variety of stresses, which may be inevitable and noxious sometimes. During evolution, animals must have acquired some physiological means to counteract stress. Vascular endothelial growth factor (VEGF) is an angiogenic and... |