9-乙基鸟嘌呤
9-乙基鸟嘌呤结构式
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常用名 | 9-乙基鸟嘌呤 | 英文名 | 9-ethylguanine |
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| CAS号 | 879-08-3 | 分子量 | 179.17900 | |
| 密度 | 1.68g/cm3 | 沸点 | 486.1ºC at 760 mmHg | |
| 分子式 | C7H9N5O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 247.8ºC |
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Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity.
Dalton Trans. 44(8) , 3614-23, (2015) Chemotherapeutics for the treatment of tumorigenic conditions that feature novel modes of action are highly sought after to overcome the limitations of current chemotherapies. Herein, we report the conjugation of the alkylating agent chlorambucil to the RAPTA... |
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Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.
Chem. Commun. (Camb.) 49(32) , 3348-50, (2013) Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound. |
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Amide linkage isomerism as an activity switch for organometallic osmium and ruthenium anticancer complexes.
J. Med. Chem. 52(23) , 7753-64, (2009) We show that the binding mode adopted by picolinamide derivatives in organometallic Os(II) and Ru(II) half-sandwich complexes can lead to contrasting cancer cell cytotoxicity. N-Phenyl picolinamide derivatives (XY) in Os(II) (1, 3-5, 7, 9) and Ru(II) (2, 6, 8... |
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Unprecedented head-to-head conformers of d(GpG) bound to the antitumor active compound tetrakis (mu-carboxylato)dirhodium(II,II).
J. Am. Chem. Soc. 125(35) , 10703-13, (2003) The N7/O6 equatorial binding interactions of the antitumor active complex Rh(2)(OAc)(4)(H(2)O)(2) (OAc(-) = CH(3)CO(2)(-)) with the DNA fragment d(GpG) have been unambiguously determined by NMR spectroscopy. Previous X-ray crystallographic determinations of t... |
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Novel binding interactions of the DNA fragment d(pGpG) cross-linked by the antitumor active compound tetrakis(mu-carboxylato)dirhodium(II,II).
J. Am. Chem. Soc. 125(35) , 10714-24, (2003) Insight into the N7/O6 equatorial binding interactions of the antitumor active complex Rh(2)(OAc)(4)(H(2)O)(2) (OAc(-) = CH(3)CO(2)(-)) with the nucleotide 5'-GMP and the DNA fragment d(pGpG) has been obtained by one- (1D) and two-dimensional (2D) NMR spectro... |
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Reactions of 9-substituted guanines with bromomalondialdehyde in aqueous solution predominantly yield glyoxal-derived adducts.
Org. Biomol. Chem. 2 , 1943-1950, (2004) Reactions of 9-ethylguanine, 2'-deoxyguanosine and guanosine with bromomalondialdehyde in aqueous buffers over a wide pH-range were studied. The main products were isolated and characterized by (1)H and (13)C NMR and mass spectroscopy. The final products form... |
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DNA cleavage and antitumour activity of platinum(II) and copper(II) compounds derived from 4-methyl-2-N-(2-pyridylmethyl)aminophenol: spectroscopic, electrochemical and biological investigation.
Dalton Trans. 48 , 10846-10860, (2009) The reaction of the redox-active ligand, Hpyramol (4-methyl-2-N-(2-pyridylmethyl)aminophenol) with K(2)PtCl(4) yields monofunctional square-planar [Pt(pyrimol)Cl], PtL-Cl, which was structurally characterised by single-crystal X-ray diffraction and NMR spectr... |
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Photocontrolled DNA binding of a receptor-targeted organometallic ruthenium(II) complex.
J. Am. Chem. Soc. 133 , 14098-14108, (2011) A photoactivated ruthenium(II) arene complex has been conjugated to two receptor-binding peptides, a dicarba analogue of octreotide and the Arg-Gly-Asp (RGD) tripeptide. These peptides can act as "tumor-targeting devices" since their receptors are overexpress... |
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"Lantern-shaped" platinum(III) complexes with axially bound 9-ethylguanine or 1-methylcytosine (L) of general formula [Pt(2){HN=C(Bu)O}(4)L(2)](NO(3))(2). Pacifico C, Intini FP, Nushi F, Natile G.
Bioorg. Chem. , doi: 10.1155/2010/102863, (2011)
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Organometallic half-sandwich iridium anticancer complexes.
J. Med. Chem. 54 , 3011-3026, (2011) The low-spin 5d(6) Ir(III) organometallic half-sandwich complexes [(η(5)-Cp(x))Ir(XY)Cl](0/+), Cp(x) = Cp*, tetramethyl(phenyl)cyclopentadienyl (Cp(xph)), or tetramethyl(biphenyl)cyclopentadienyl (Cp(xbiph)), XY = 1,10-phenanthroline (4-6), 2,2'-bipyridine (7... |