4a,5-二氢洛伐他汀
4a,5-二氢洛伐他汀结构式
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常用名 | 4a,5-二氢洛伐他汀 | 英文名 | dihydromevinolin |
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| CAS号 | 77517-29-4 | 分子量 | 406.55600 | |
| 密度 | 1.1g/cm3 | 沸点 | 534.8ºC at 760 mmHg | |
| 分子式 | C24H38O5 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | 174.5ºC |
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Total synthesis and biological evaluation of structural analogues of compactin and dihydromevinolin.
J. Med. Chem. 30(10) , 1858-73, (1987) The full experimental details for the total synthesis of (+)-compactin and 19 structural analogues are reported. We have evaluated three classes of analogues as inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase: (1) functional and stereoisomeric a... |
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Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus.
J. Antibiot. 34(5) , 507-12, (1981) A new, potent hypocholesterolemic agent is produced by cultures of Aspergillus terreus. The isolation of the compound and its characterization as 4a,5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. Comparative data for d... |
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