(S)-Baclofen hydrochloride
(S)-Baclofen hydrochloride结构式
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常用名 | (S)-Baclofen hydrochloride | 英文名 | (S)-Baclofen hydrochloride |
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| CAS号 | 63701-56-4 | 分子量 | 250.12200 | |
| 密度 | N/A | 沸点 | 364.3ºC at 760mmHg | |
| 分子式 | C10H13Cl2NO2 | 熔点 | 223 - 224 °C | |
| MSDS | 美版 | 闪点 | 174.1ºC |
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Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat.
Eur. J. Pharmacol. 196 , 267, (1991) In a previous study it was found that i.t. administration of L-baclofen decreased arterial pressure and heart rate while D-baclofen differentially increased arterial pressure. The objective of the present study was to determine which of these effects was bloc... |
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Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.
J. Neurochem. 47 , 898, (1986) The affinities of a number of analogues of gamma-aminobutyric acid (GABA) for GABAA and GABAB receptor sites and GABA uptake were studied using rat brain membrane preparations. Studies on the (S)-(+)- and (R)-(-)-isomers of baclofen, 3-hydroxy-4-aminobutyric ... |
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3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.
Pol. J. Pharmacol. Pharm. 32 , 187, (1980) Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enantiomers has been determined. The R(+) enantiomer was found to... |
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Stereospecific actions of baclofen on sociosexual behavior, locomotor activity and motor execution.
Psychopharmacology 97 , 358, (1989) The behavior effects of racemic baclofen and the R and S enantiomers were studied in order to determine whether the stereospecificity found in receptor binding studies also applies to the behavioral actions of the drug. Racemic and R-baclofen inhibited sexual... |