阿帕泛
阿帕泛结构式
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常用名 | 阿帕泛 | 英文名 | Apafant |
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| CAS号 | 105219-56-5 | 分子量 | 455.96 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 720.2±70.0 °C at 760 mmHg | |
| 分子式 | C22H22ClN5O2S | 熔点 | 186-188ºC | |
| MSDS | 中文版 美版 | 闪点 | 389.4±35.7 °C |
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A pepducin derived from the third intracellular loop of FPR2 is a partial agonist for direct activation of this receptor in neutrophils but a full agonist for cross-talk triggered reactivation of FPR2.
PLoS ONE 9(10) , e109516, (2014) We recently described a novel receptor cross-talk mechanism in neutrophils, unique in that the signals generated by the PAF receptor (PAFR) and the ATP receptor (P2Y2R) transfer formyl peptide receptor 1 (FPR1) from a desensitized (non-signaling) state back t... |
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Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages.
PLoS ONE 5(11) , e13815, (2010) Studies on the role of neutrophils in Leishmania infection were mainly performed with L. (L) major, whereas less information is available for L. (L) amazonensis. Previous results from our laboratory showed a large infiltrate of neutrophils in the site of infe... |
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Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 308(3) , R163-72, (2015) Preeclampsia is a disorder of pregnancy with a significant impact on maternal and fetal health. The complexity of this multifactorial condition has precluded development of effective therapies and, although many potential pathways have been investigated, the ... |
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Rupatadine effectively prevents the histamine-induced up regulation of histamine H1R and bradykinin B2R receptor gene expression in the rat paw.
Pharmacol. Rep. 66(6) , 952-5, (2014) Activation of histamine H1 receptor (H1R) is a well-known hallmark of allergic and inflammatory pathology. Both types of bradykinin receptors (B1R and B2R) are also known to contribute significantly to the latter and some sort of functional interaction betwee... |
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A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation.
Biochem. Pharmacol. 93(4) , 482-95, (2015) Platelet-activating factor (PAF) is a well-known phospholipid that mediates acute inflammatory responses. In the present study, we investigated whether PAF/PAF receptor signaling contributed to chronic inflammation in the white adipose tissue (WAT) of PAF rec... |
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The expression of platelet-activating factor receptor modulates the cisplatin sensitivity of ovarian cancer cells: a novel target for combination therapy.
Br. J. Cancer 111(3) , 515-24, (2014) Ovarian cancer has the highest mortality rate of the gynaecological cancers. Although cisplatin (CDDP) is an effective treatment for ovarian cancer, recurrence is frequent and leads to death. The objective was to explore the role and possible mechanisms of pl... |
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Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity.
Pancreas 38(1) , 58-64, (2009) Platelet-activating factor (PAF) is an important mediator of inflammation and postulated to be involved in the pathogenesis of acute pancreatitis. In this study, we evaluated the therapeutic effect of PAF antagonist WEB 2086 in acute experimental pancreatitis... |
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Expression of PAFR as part of a prosurvival response to chemotherapy: a novel target for combination therapy in melanoma.
Mediators Inflamm. 2012 , 175408, (2012) Melanoma cells express the platelet-activating factor receptor (PAFR) and, thus, respond to PAF, a bioactive lipid produced by both tumour cells and those in the tumour microenvironment such as macrophages. Here, we show that treatment of a human melanoma SKm... |
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WEB 2086, a platelet-activating factor antagonist, inhibits prophenoloxidase-activating system and hemocyte microaggregation reactions induced by Trypanosoma rangeli infection in Rhodnius prolixus hemolymph.
J. Insect Physiol. 52(7) , 685-92, (2006) The effects of the triazolodiazepine WEB 2086, a platelet-activating factor (PAF) antagonist, on hemocyte microaggregation and prophenoloxidase (proPO)-activating system in the hemolymph, hemocoelic infection and mortality in fifth-instar larvae of Rhodnius p... |
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Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw.
Biochem. Pharmacol. 77(7) , 1223-35, (2009) Platelet-activating factor (PAF) is an inflammatory mediator widely known to exert relevant pathophysiological functions. However, the relevance of PAF in nociception has received much less attention. Herein, we have investigated the mechanisms underlying PAF... |