N-乙酰氧基-N-乙酰基-4-氯苯磺酰胺
N-乙酰氧基-N-乙酰基-4-氯苯磺酰胺结构式
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常用名 | N-乙酰氧基-N-乙酰基-4-氯苯磺酰胺 | 英文名 | n-acetyl-n-acetoxy-4-chlorobenzenesulfonamide |
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| CAS号 | 142867-52-5 | 分子量 | 291.70800 | |
| 密度 | 1.454 g/cm3 | 沸点 | 401.4ºC at 760 mmHg | |
| 分子式 | C10H10ClNO5S | 熔点 | 119-122ºC | |
| MSDS | 中文版 美版 | 闪点 | 196.6ºC |
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Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase.
J. Med. Chem. 35 , 3648, (1992) In the preceding paper, analogs of chlorpropamide with an OMe substituent on the sulfonamide nitrogen were shown to inhibit aldehyde dehydrogenase (AlDH), and it was postulated that these compounds were bioactivated by O-demethylation to release nitroxyl (HN ... |
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N,O-diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties.
Biochem. Biophys. Res. Commun. 187 , 1367, (1992) N,O-Diacylated-N-hydroxyarylsulfonamides are capable of slowly releasing nitroxyl (HNO) by simple, non-enzymatic hydrolysis in Krebs solution at 37 degrees C. Release of nitric oxide (NO) was not seen. These compounds were also found to elicit vasorelaxation ... |
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