神经节苷脂
神经节苷脂结构式
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常用名 | 神经节苷脂 | 英文名 | Ganglioside GM1, Asialo |
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| CAS号 | 71012-19-6 | 分子量 | 1272.60000 | |
| 密度 | 1.28 g/cm3 | 沸点 | 1302ºC at 760 mmHg | |
| 分子式 | C62H117N3O23 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 741.2ºC |
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Fuzheng Huayu inhibits carbon tetrachloride-induced liver fibrosis in mice through activating hepatic NK cells.
J. Ethnopharmacol. 145(1) , 175-81, (2013) Fuzheng Huayu (FZHY) is a Chinese compound herbal preparation which consists of six Chinese herbs. This study examines the preventative effects of FZHY on liver fibrosis induced by carbon tetrachloride (CCl(4)) and explores its possible mechanisms of action.L... |
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Sex-dependent liver colonization of human melanoma in SCID mice--role of host defense mechanisms.
Clin. Exp. Metastasis 30(4) , 497-506, (2013) The possibility that endocrine factors may influence the clinical course of malignant melanoma is suggested by the superior survival data of women. In preclinical models we observed a higher rate of colony formation by human melanoma cells in male compared to... |
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T lymphocytes restrain spontaneous metastases in permanent dormancy.
Cancer Res. 74(7) , 1958-68, (2014) Tumor dormancy is a clinical phenomenon related to immune equilibrium during cancer immunoediting. The mechanisms involved in dormant metastases are poorly understood due to the lack of preclinical models. Here, we present a nontransgenic mouse model in which... |
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Segregative clustering of Lo and Ld membrane microdomains induced by local pH gradients in GM1-containing giant vesicles: a lipid model for cellular polarization.
Langmuir 28(47) , 16327-37, (2012) Several cell polarization processes are coupled to local pH gradients at the membrane surface. We have investigated the involvement of a lipid-mediated effect in such coupling. The influence of lateral pH gradients along the membrane surface on lipid microdom... |
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NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors.
Mech. Ageing Dev. 130(6) , 384-92, (2009) E2A encoded proteins, key transcriptional regulators in B lineage specification and commitment, have been shown to decrease in B cell precursors in old age. E2A regulates genes encoding the surrogate light chain proteins lambda5 and VpreB. In old age, B cell ... |
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NK depletion results in increased CCL22 secretion and Treg levels in Lewis lung carcinoma via the accumulation of CCL22-secreting CD11b+CD11c+ cells.
Int. J. Cancer 127(11) , 2598-611, (2010) Tumor-induced immune suppression involves the accumulation of suppressive infiltrates in the tumor microenvironment such as regulatory T-cells (Tregs). Previous studies demonstrated that NK-dependant increases in CCL22 secretion selectively recruit Tregs towa... |
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Impaired dendritic cell functions because of depletion of natural killer cells disrupt antigen-specific immune responses in mice: restoration of adaptive immunity in natural killer-depleted mice by antigen-pulsed dendritic cell.
Clin. Exp. Immunol. 152(1) , 174-81, (2008) The primary aim of this study was to evaluate the role of natural killer (NK) cells on antigen-specific adaptive immune responses. After analysing the mechanism of impaired adaptive immune responses of NK-depleted mice, an immune interventional approach was d... |
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NK cells interfere with the generation of resistance against mycoplasma respiratory infection following nasal-pulmonary immunization.
J. Immunol. 183(4) , 2622-31, (2009) The purpose of the present study was to determine the impact of NK cells on the development of protective adaptive immunity in response to nasal-pulmonary immunization against mycoplasma. Depletion of NK cells before nasal-pulmonary immunization enhanced resi... |
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Antibodies to ganglioside complexes consisting of asialo-GM1 and GQ1b or GT1a in Fisher and Guillain-Barré syndromes.
J. Neuroimmunol. 214(1-2) , 125-7, (2009) To determine the epitopes of ganglioside complexes (GSCs) containing GQ1b or GT1a, we investigated their reactivity to GSCs consisting of asialo-GM1 (GA1) and GQ1b or GT1a using IgG anti-GQ1b- or anti-GT1a-positive sera. Nine anti-GQ1b-positive sera had highe... |
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Neuritogenic effects of T cell-derived IL-3 on mouse splenic sympathetic neurons in vivo.
J. Immunol. 180(6) , 4227-34, (2008) To determine the role played by lymphocytes and cytokines in the growth of sympathetic neurons in vivo, the innervation and cytokine levels were examined in the spleens of SCID mice that lack T and B cells. Splenic noradrenaline, nerve growth factor (NGF), an... |