硫酸巴龙霉素
硫酸巴龙霉素结构式
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常用名 | 硫酸巴龙霉素 | 英文名 | Paromomycin Sulfate |
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| CAS号 | 1263-89-4 | 分子量 | 713.707 | |
| 密度 | N/A | 沸点 | 939.8ºC at 760 mmHg | |
| 分子式 | C23H47N5O18S | 熔点 | >200ºC | |
| MSDS | 中文版 美版 | 闪点 | 522.2ºC |
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Aminoglycosides suppress the protein folding activity of the molecular chaperone HSC70: implication of a structure-activity relationship.
Chemotherapy 60(1) , 37-46, (2014) The mechanism of aminoglycoside (AG)-induced nephrotoxicity has not been fully elucidated. We previously reported that gentamicin suppresses the functions of HSC70, a heat shock cognate protein, which is a cytosolic molecular chaperone in mammalian cells. How... |
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Generation of transgenic energy cane plants with integration of minimal transgene expression cassette.
Curr. Pharm. Biotechnol. 16(5) , 407-13, (2015) Lignocellulosic biomass has the potential to serve as feedstock and direct replacement for petrochemicals in the fuel, chemical, pharmaceutical and material industries. Energy cane has been identified by the U.S. Department of Energy (DOE) as prime lignocellu... |
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Mixed-mode liquid chromatography coupled to tandem mass spectrometry for the analysis of aminoglycosides in meat.
Anal. Bioanal. Chem 406(20) , 4941-53, (2014) A novel LC-MS/MS method has been developed for the determination of 13 aminoglycoside antibiotics in meat products. Among the chromatographic columns tested, the mixed-mode Obelisc R provided the best performance. Electrospray has been used for the coupling o... |
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Leishmania tropica in children: a retrospective study.
J. Am. Acad. Dermatol. 71(2) , 271-7, (2014) Limited data are available regarding topical and systemic therapies for Leishmania tropica in children.We sought to characterize the clinical presentation and evaluate the efficacy and safety of topical and systemic treatments in pediatric patients infected w... |
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Clinical aspects of paediatric visceral leishmaniasis in North-west Ethiopia.
Trop. Med. Int. Health 20(1) , 8-16, (2015) Visceral leishmaniasis (VL) in north-west Ethiopia is causing an overwhelming case load among adult migrant workers that masked the disease burden in children. This study describes the clinical profile and explores comorbidities in paediatric VL patients.A pr... |
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Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration.
Biomaterials 75 , 25-36, (2015) The use of artificial tissues in regenerative medicine is limited due to hypoxia. As a strategy to overcome this drawback, we have shown that photosynthetic biomaterials can produce and provide oxygen independently of blood perfusion by generating chimeric an... |
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Motor domain-based motility system and motile properties of alpha heavy chain in Tetrahymena outer arm dynein.
Biochem. Biophys. Res. Commun. 453(3) , 595-9, (2014) Axonemal dynein plays an essential role in ciliary motility, and impaired ciliary motility causes human diseases such as primary ciliary dyskinesia (PCD). The motor domain of axonemal dynein powers ciliary motility and its function is regulated by several acc... |
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Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance.
Front. Microbiol. 6 , 354, (2015) Antimicrobial chemotherapy is critical in the fight against infectious diseases caused by Entamoeba histolytica. Among the drugs available for the treatment of amebiasis, metronidazole (MTZ) is considered the drug of choice. Recently, in vitro studies have de... |
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Aminoglycoside analysis in food of animal origin with a zwitterionic stationary phase and liquid chromatography-tandem mass spectrometry.
Anal. Chim. Acta 882 , 127-39, (2015) In this study, fourteen highly polar aminoglycoside (AGs) antibiotics were selected. Various stationary phases were tested, including Obelisc R, ZIC-HILIC, BEH amide and aminopropyl. The nature of the stationary phase, mobile phase (water or buffer solutions ... |
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Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis.
Biochemistry 54 , 3197-206, (2015) Proteins from the enhanced intracellular survival (Eis) family are versatile acetyltransferases that acetylate amines at multiple positions of several aminoglycosides (AGs). Their upregulation confers drug resistance. Homologues of Eis are present in diverse ... |