双去氧基姜黄素
双去氧基姜黄素结构式
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常用名 | 双去氧基姜黄素 | 英文名 | Bisdemethoxycurcumin |
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| CAS号 | 24939-16-0 | 分子量 | 308.328 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 551.3±45.0 °C at 760 mmHg | |
| 分子式 | C19H16O4 | 熔点 | 91-93℃ | |
| MSDS | 中文版 | 闪点 | 301.3±25.2 °C |
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Bis-demethoxy curcumin analog nanoparticles: synthesis, characterization, and anticancer activity in vitro.
J. Nanosci. Nanotechnol. 14(7) , 4865-73, (2014) We have optimized a protocol for the preparation of bisdemethoxy curcumin analog nanoparticles (BDMCA-NP) by the solvent assisted process. The structural similarities between bulk and nano BDMCA were determined by Co-TLC, NMR and F-TIR. This shows that our sy... |
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Therapeutic potential of turmeric in Alzheimer's disease: curcumin or curcuminoids?
Phytother Res. 28(4) , 517-25, (2014) Alzheimer's disease (AD) is the most common form of dementia. There is limited choice in modern therapeutics, and drugs available have limited success with multiple side effects in addition to high cost. Hence, newer and alternate treatment options are being ... |
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Differential cellular uptake and metabolism of curcuminoids in monocytes/macrophages: regulatory effects on lipid accumulation.
Br. J. Nutr. 112(1) , 8-14, (2014) We have previously shown that curcumin (CUR) may increase lipid accumulation in cultured human acute monocytic leukaemia cell line THP-1 monocytes/macrophages, but that tetrahydrocurcumin (THC), an in vivo metabolite of CUR, has no such effect. In the present... |
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Molecularly imprinted polymers for cleanup and selective extraction of curcuminoids in medicinal herbal extracts.
Anal. Bioanal. Chem 407(3) , 803-12, (2015) This paper describes the synthesis of novel molecularly imprinted polymers (MIPs), prepared by a noncovalent imprinting approach, for cleanup and preconcentration of curcumin (CUR) and bisdemethoxycurcumin (BDMC) from medicinal herbal extracts and further ana... |
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A novel approach to active compounds identification based on support vector regression model and mean impact value.
Chem. Biol. Drug Des. 81(5) , 650-7, (2013) Traditionally, active compounds were discovered from natural product extracts by bioassay-guided fractionation, which was with high cost and low efficiency. A well-trained support vector regression model based on mean impact value was used to identify lead ac... |
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Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer.
Curr. Pharm. Des. 19(34) , 6218-25, (2013) While the chemotherapeutic effect of curcumin, one of three major curcuminoids derived from turmeric, has been reported, largely unexplored are the effects of complex turmeric extracts more analogous to traditional medicinal preparations, as well as the relat... |
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Simultaneous determination of threeCurcuminoidsinCurcuma wenyujin Y.H.chen et C.Ling. by liquid chromatography–tandem mass spectrometry combined with pressurized liquid extraction
J. Pharm. Biomed. Anal. 81-82 , 146-50, (2013) A method based on pressurized liquid extraction (PLE) followed by determination with liquid chromatography–tandem mass spectrometry (LC–MS/MS) was developed for identification and quantification of Curcumin, Demethoxycurcumin and Bisdemethoxycurcumin in Curcu... |
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The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells.
Taiwan. J. Obstet. Gynecol. 51(3) , 368-74, (2012) Curcuminoids (including curcumin) are natural antioxidants demonstrating potent chemopreventive properties against several forms of cancer. This study investigated the antiproliferative and induced apoptotic effects of curcuminoids on three cell lines isolate... |
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A reduced curcuminoid analog as a novel inducer of fetal hemoglobin.
Ann. Hematol. 92(3) , 379-86, (2013) Thalassemia is an inherited disorder of hemoglobin molecules that is characterized by an imbalance of α- and β-globin chain synthesis. Accumulation of unbound α-globin chains in erythroid cells is the major cause of pathology in β-thalassemia. Stimulation of ... |
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Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice
Exp. Parasitol. 131(3) , 292-9, (2012) Graphical abstract On day 6, blood smears and staining for parasites from control animals (no treatment) showed a high parasitemia and many parasites in the ring stages (A). But for animals treated with 40mg/kg body weight of curcuminoids-loaded liposomes, th... |